PDF(Pubmed)
Abstract：
This systematic review paper aimed to assess and analyze the prevalence of maternal colonization of Staphylococcus aureus (S. aureus) also known as methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) in the peripartum period and its significance on vertical transmission to the neonate and if it is a potential threat to the health of newborns. For this, multiple databases, such as PubMed, MEDLINE, ScienceDirect, and the database of Elsevier, were used to scout for relevant articles, and results were reported adhering to the principles set by Preferred Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines 2020. A specific medical subject headings (MeSH) criterion was designed to search for relevant publications on PubMed. A total of 26 articles were finally selected after a meticulous screening process, including detailed inclusion and exclusion criteria, manual reading of titles and abstracts, and availability of accessible full-text articles. A few articles were also selected after going through the citations section of the initially selected papers. Quality appraisal was done on the selected publications. Maternal colonization of S. aureus is determined to be highly prevalent with the hypothesis that nasal colonization had higher rates than recto-vaginal sites. Increasing maternal age, history of vaginitis, and multiparity were the most common risk factors for MRSA and MSSA colonization. Premature babies were at the highest risk of MRSA colonization. Breast milk is also a risk factor for neonatal MRSA transmission. Through this systematic review, we concluded that although the rate of vertical transmission of MRSA is lower than that of MSSA, we felt that it held significance as neonates with the bug have poor outcomes due to skin and soft tissue infections and there is spread of MRSA to other neonates in the wards and spread to siblings in cases of triplets and quadruplets and even death due to potential MRSA sepsis. Women in Africa and China had high prevalence rates of MRSA and S. aureus which can probably be attributed to a lack of access to adequate healthcare facilities. We recommend screening with regular recto-vaginal swabs and nasal swabs especially in regions with a high burden of MRSA to be performed at regular intervals after confirmation of pregnancy, as prevention and screening are effective to avoid serious complications.
摘要：
这篇系统综述论文旨在评估和分析孕妇金黄色葡萄球菌定植的患病率(S.金黄色葡萄球菌）在围产期也被称为甲氧西林敏感金黄色葡萄球菌（MSSA）和耐甲氧西林金黄色葡萄球菌（MRSA），其对新生儿垂直传播的意义以及对新生儿健康的潜在威胁。为此，多个数据库，比如PubMed,MEDLINE,ScienceDirect,和爱思唯尔的数据库，被用来侦察相关文章，报告的结果遵循了2020年系统评价和荟萃分析（PRISMA）指南的首选项目设定的原则。设计了特定的医学主题词（MeSH）标准，以搜索PubMed上的相关出版物。经过细致的筛选过程,最终选出共26篇文章,包括详细的纳入和排除标准，手动阅读标题和摘要，以及可访问的全文文章的可用性。在通过最初选择的论文的引文部分之后，还选择了一些文章。对选定的出版物进行了质量评估。金黄色葡萄球菌的母体定植被确定为非常普遍,假设鼻定植具有比直肠阴道部位更高的比率。增加产妇年龄,阴道炎病史,和多重均等是MRSA和MSSA定植的最常见危险因素。早产儿MRSA定植的风险最高。母乳也是新生儿MRSA传播的危险因素。通过这次系统的审查,我们的结论是，尽管MRSA的垂直传播率低于MSSA，我们认为这具有重要意义,因为感染细菌的新生儿由于皮肤和软组织感染而结局不佳,并且MRSA在病房中传播到其他新生儿,在三胞胎和四胞胎的情况下传播到兄弟姐妹,甚至由于潜在的MRSA败血症而死亡.非洲和中国的妇女MRSA和金黄色葡萄球菌的患病率很高，这可能归因于缺乏足够的医疗保健设施。我们建议定期使用直肠阴道拭子和鼻拭子进行筛查，特别是在MRSA高负担的地区，在确认怀孕后定期进行。预防和筛查可有效避免严重并发症。
