PDF(Pubmed)
Abstract：
In a broad sense, Rickettsiae are a group of microorganisms that can be transmitted mechanically or biologically to animals and humans. Rickettsioses are associated with hematic manifestations. Its prevalence in humans, dogs and other animals has been widely explored, but not in equine species. To determine the prevalence of Rickettsia infection in horses. A systematic review of the literature was carried out in five databases for the proportion of horses infected with Rickettsia, defined by molecular and immunological techniques. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CI). The Cochran\'s Q test and the I2 statistic were used to assess the between-study-heterogeneity. The pooled prevalence of Rickettsia in equines was 37.0% (95% CI: 26.0%-47.0%), with significant heterogeneity among studies (I2 = 98.12%). In the subgroup analysis, the prevalence of Rickettsia in horses was found to be 24.0% (95%CI: 10.0%-41.0%) for IFI, 47.0% (95%CI: 30.0%-64.0%) for IFA, 14.0% (95%CI: 11.0%-17.0%) for IFAT and 39.0% (95%CI: 0.0%-95.0%) for PCR. There was a high prevalence of Rickettsia among horses, with some of the species being zoonotic, with their corresponding implications for humans, which increasingly are in close contact with equines, particularly horses and their ticks, posing a risk for spillover and transmission.
摘要：
在广义上,立克次体是一组可以机械或生物传播给动物和人的微生物。立克次体病与血液表现有关。它在人类中的流行，狗和其他动物已经被广泛探索，但不是在马种。确定马立克次体感染的患病率。在五个数据库中对感染立克次体的马的比例进行了文献的系统回顾，由分子和免疫学技术定义。使用随机效应模型进行荟萃分析，以计算合并的患病率和95％置信区间（CI）。CochranQ检验和I2统计量用于评估研究之间的异质性。马中立克次体的合并患病率为37.0％（95％CI：26.0％-47.0％），研究间存在显著异质性(I2=98.12%)。在亚组分析中，结果发现马立克次体的患病率为24.0%(95CI:10.0%-41.0%)，IFA的47.0%（95CI：30.0%-64.0%），IFAT为14.0%（95CI：11.0%-17.0%），PCR为39.0%（95CI：0.0%-95.0%）。马中立克次体的患病率很高，有些物种是人畜共患的，它们对人类的相应影响，越来越多地与马接触，尤其是马和它们的蜱,对溢出和传播构成风险。
