PDF(Pubmed)
Abstract：
Clostridioide difficile is the leading cause of diarrhea disease worldwide and is a CDC-designated urgent threat level pathogen. Mammalian models are commonly utilized as gold standard to study the pathogenesis of C. difficile infection (CDI); however, alternatives are needed due to cost, higher throughput ability, and mammalian animal ethics. Nonmammalian models such as great wax worm, nematode, fruit fly, and zebrafish have been used as CDI models. This review provides a comprehensive summary of nonmammalian models used to study CDI. Multiple studies were identified using these models to study C. difficile infection, pathogenicity, colonization, host immunity, and therapy. Translational outcomes and strength and weakness of each nonmammalian model are discussed.
摘要：
艰难梭菌是世界范围内腹泻疾病的主要原因，是CDC指定的紧急威胁级别病原体。哺乳动物模型通常被用作研究艰难梭菌感染（CDI）发病机理的金标准；然而，由于成本原因，需要替代品，更高的吞吐能力，和哺乳动物伦理。非哺乳动物模型，如大蜡虫，线虫,果蝇,斑马鱼已被用作CDI模型。这篇综述提供了用于研究CDI的非哺乳动物模型的全面总结。使用这些模型确定了多项研究来研究艰难梭菌感染，致病性，殖民,宿主免疫,和治疗。讨论了每个非哺乳动物模型的转化结果和优缺点。
