Abstract：
The skin is the largest barrier organ of the human body and serves to protect the internal structure of the body from the harmful environment. The epidermis forms the outermost layer and is exposed to the environment. Keratinocytes are important constituent cells of the epidermis and alter their morphology and structural integrity through a highly complex differentiation process referred to as cornification. Abnormalities in the process of epidermal cornification can lead to skin barrier dysfunction. The epidermal differentiation complex (EDC) is a gene cluster located within a 2 Mb region of human chromosome 1q21. EDC is responsible for epithelial tissue development and for properties of the stratum corneum. One of the most important features of psoriasis is the abnormal terminal differentiation of keratinocytes. However, the relationship between EDC and the occurrence of psoriasis is still unclear. In this review, we summarize current knowledge regarding the physiological functions of EDC and discuss its possible contributions to the pathogenesis of psoriasis.
摘要：
皮肤是人体最大的屏障器官，用于保护人体内部结构免受有害环境的影响。表皮形成最外层并暴露于环境。角质形成细胞是表皮的重要组成细胞,并通过称为角质化的高度复杂的分化过程改变其形态和结构完整性。表皮角化过程中的异常可导致皮肤屏障功能障碍。表皮分化复合物(EDC)是位于人染色体1q21的2Mb区域内的基因簇。EDC负责上皮组织发育和角质层的性质。银屑病最重要的特征之一是角质形成细胞的异常终末分化。然而,EDC与银屑病发生的关系尚不清楚。在这次审查中,我们总结了有关EDC生理功能的现有知识，并讨论了其对银屑病发病机理的可能贡献。
