Abstract：
BACKGROUND: We report a case and discuss the clinical characteristics and treatment of spontaneous Descemet membrane detachment (DMD).
METHODS: We describe a rare case of spontaneous DMD in a patient with prior anterior uveitis and provide a review of the current literature. A 20-year-old woman with a prior history of anterior uveitis presented with vision loss in the left eye. The slit-lamp examination showed corneal edema secondary to DMD, confirmed by anterior segment optical coherence tomography (AS-OCT). The patient underwent an intracameral injection of 20% sulphur hexafluoride (SF6) with complete resolution of the DMD. Although rare, several cases of spontaneous DMD have been reported in the literature, mostly occurring after intraocular surgery. We searched the Pubmed database (1949-2021) for peer-reviewed publications relevant to the topic of spontaneous DMD.
CONCLUSIONS: The pathogenesis of spontaneous DMD is complex and depends on several factors. It can occur due to anatomical anomalies, inflammatory disease, trauma, chemical injuries, and surgical or laser procedures. In most cases, early diagnosis and appropriate management led to resolution.
METHODS: We describe a rare case of spontaneous DMD in a patient with prior anterior uveitis and provide a review of the current literature. A 20-year-old woman with a prior history of anterior uveitis presented with vision loss in the left eye. The slit-lamp examination showed corneal edema secondary to DMD, confirmed by anterior segment optical coherence tomography (AS-OCT). The patient underwent an intracameral injection of 20% sulphur hexafluoride (SF6) with complete resolution of the DMD. Although rare, several cases of spontaneous DMD have been reported in the literature, mostly occurring after intraocular surgery. We searched the Pubmed database (1949-2021) for peer-reviewed publications relevant to the topic of spontaneous DMD.
CONCLUSIONS: The pathogenesis of spontaneous DMD is complex and depends on several factors. It can occur due to anatomical anomalies, inflammatory disease, trauma, chemical injuries, and surgical or laser procedures. In most cases, early diagnosis and appropriate management led to resolution.
摘要：
背景：我们报告了一例自发性脱粒膜脱离（DMD）的临床特征和治疗方法。
方法：我们描述了一例罕见的前葡萄膜炎患者的自发性DMD病例，并对目前的文献进行了综述。一名20岁的女性，既往有前葡萄膜炎病史，左眼视力下降。裂隙灯检查显示DMD继发角膜水肿，经眼前节光学相干断层扫描（AS-OCT）证实。患者接受了20％六氟化硫（SF6）的前房内注射，并完全消除了DMD。虽然罕见，文献中已经报道了几例自发性DMD，主要发生在眼内手术后。我们在Pubmed数据库（1949-2021）中搜索了与自发性DMD主题相关的同行评审出版物。
结论：自发性DMD的发病机制复杂，取决于多种因素。它可能是由于解剖异常而发生的，炎症性疾病，创伤,化学损伤,和手术或激光手术。在大多数情况下,早期诊断和适当的管理导致解决。
方法：我们描述了一例罕见的前葡萄膜炎患者的自发性DMD病例，并对目前的文献进行了综述。一名20岁的女性，既往有前葡萄膜炎病史，左眼视力下降。裂隙灯检查显示DMD继发角膜水肿，经眼前节光学相干断层扫描（AS-OCT）证实。患者接受了20％六氟化硫（SF6）的前房内注射，并完全消除了DMD。虽然罕见，文献中已经报道了几例自发性DMD，主要发生在眼内手术后。我们在Pubmed数据库（1949-2021）中搜索了与自发性DMD主题相关的同行评审出版物。
结论：自发性DMD的发病机制复杂，取决于多种因素。它可能是由于解剖异常而发生的，炎症性疾病，创伤,化学损伤,和手术或激光手术。在大多数情况下,早期诊断和适当的管理导致解决。
