PDF(Pubmed)
Abstract：
This study investigated the impact of residential radon exposure on human cancers (i.e., lung cancer and childhood leukemia) through a systematic review and meta-analysis of case−control studies. A total of 9724 articles obtained from electronic databases were assessed; however, only 55 case−control studies were eligible after manually screening and eliminating unnecessary studies. The causal associations were addressed by determining the meta-analysis’s estimated size effects (i.e., ORs/RRs) of the meta-analysis. Residential radon was revealed to significantly increase the incidence of lung cancer and childhood leukemia with pooled ORs of 1.38 [1.19; 1.60] (I2 = 90%; p < 0.00001) and 1.43 [1.19; 1.72] (I2 = 0% and p = 0.51), respectively. In addition, subgroup analyses were performed to reduce the heterogeneity of the initial meta-analyses. The results provided strong evidence that inhaling radon in the indoor environments is closely associated with the development of lung cancer and childhood leukemia in patients living in Europe and areas with high radon levels (≥100 Bq/m3).
摘要：
这项研究调查了住宅氡暴露对人类癌症的影响(即，肺癌和儿童白血病）通过对病例对照研究的系统评价和荟萃分析。总共评估了从电子数据库获得的9724篇文章；然而，在人工筛查和取消不必要的研究后,只有55项病例对照研究符合资格.通过确定荟萃分析的估计大小效应(即，ORs/RR)的荟萃分析。发现住宅氡显著增加肺癌和儿童白血病的发病率，合并OR为1.38[1.19;1.60](I2=90%;p<0.00001)和1.43[1.19;1.72](I2=0%和p=0.51)，分别。此外,进行亚组分析以减少初始meta分析的异质性.结果提供了强有力的证据，表明在室内环境中吸入氡与生活在欧洲和氡水平高（≥100Bq/m3）地区的患者肺癌和儿童白血病的发展密切相关。
