Abstract：
Teleosts rely on innate immunity to recognize and defense against pathogenic microorganisms. RIG-I-like receptor (RLR) family is the major pattern recognition receptor (PRR) to detect RNA viruses. After recognition of viral RNA components, these cytosolic sensors activate downstream signaling cascades to induce the expression of type I interferons (IFNs) and other cytokines firing antiviral responses. Meanwhile, numerous molecules take part in the complex regulation of RLR signals by various methods, such as post-translational modification (PTM), to produce an immune response that is appropriately balanced. In this review, we summarize our recent understanding of PTMs and other regulatory proteins in modulating RLR signaling pathway, which is helpful for systematically studying the regulatory mechanism of antiviral innate immunity of teleost fish.
摘要：
硬骨鱼依靠先天免疫来识别和防御病原微生物。RIG-I样受体（RLR）家族是检测RNA病毒的主要模式识别受体（PRR）。识别病毒RNA成分后，这些细胞溶质传感器激活下游信号级联，以诱导I型干扰素（IFN）和其他细胞因子激发抗病毒反应的表达。同时,许多分子通过各种方法参与RLR信号的复杂调节，如翻译后修饰（PTM），产生适当平衡的免疫反应。在这次审查中,我们总结了我们最近对PTM和其他调节蛋白在调节RLR信号通路中的理解，这有助于系统研究硬骨鱼抗病毒先天免疫的调控机制。
