Abstract：
OBJECTIVE: To compare the fetal pulmonary artery Doppler indices of pregnant women with autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren\'s syndrome (SS), and antiphospholipid syndrome (APS) with healthy pregnant women.
METHODS: Thirty-nine pregnancies were included in the case group, 19 of them SLE, 12 with SS, and eight with APS. The gestational age-matched 54 healthy pregnant women were included in the control group. Peak systolic velocity, time-averaged velocity, systolic/diastolic ratio, pulsatility index, resistance index, acceleration time (AT), ejection time (ET), and AT/ET ratio were obtained from pulmonary artery waveform by using spectral Doppler ultrasound.
RESULTS: Significantly shorter AT and lower AT/ET ratio were detected in the case group (p = < .001, p = < .001, respectively). The shortening of AT and decreasing of the AT/ET ratio were more predominant in the APS group. However, there was no significant difference between the SLE, SS, and APS groups in fetal pulmonary artery Doppler indices. Also, a moderate correlation was found between maternal disease duration (years) and fetal pulmonary artery AT (r = -.516, p = .001) and AT/ET ratio (r = -.558, p = < .001).
CONCLUSIONS: Fetal pulmonary artery Doppler indices may be affected in maternal autoimmune diseases. Further studies are needed to evaluate fetal pulmonary Doppler indices such as AT and AT/ET ratio to predict neonatal respiratory morbidity and lung maturation in pregnant women with SLE, SS, and APS.
METHODS: Thirty-nine pregnancies were included in the case group, 19 of them SLE, 12 with SS, and eight with APS. The gestational age-matched 54 healthy pregnant women were included in the control group. Peak systolic velocity, time-averaged velocity, systolic/diastolic ratio, pulsatility index, resistance index, acceleration time (AT), ejection time (ET), and AT/ET ratio were obtained from pulmonary artery waveform by using spectral Doppler ultrasound.
RESULTS: Significantly shorter AT and lower AT/ET ratio were detected in the case group (p = < .001, p = < .001, respectively). The shortening of AT and decreasing of the AT/ET ratio were more predominant in the APS group. However, there was no significant difference between the SLE, SS, and APS groups in fetal pulmonary artery Doppler indices. Also, a moderate correlation was found between maternal disease duration (years) and fetal pulmonary artery AT (r = -.516, p = .001) and AT/ET ratio (r = -.558, p = < .001).
CONCLUSIONS: Fetal pulmonary artery Doppler indices may be affected in maternal autoimmune diseases. Further studies are needed to evaluate fetal pulmonary Doppler indices such as AT and AT/ET ratio to predict neonatal respiratory morbidity and lung maturation in pregnant women with SLE, SS, and APS.
摘要：
目的:比较妊娠合并系统性红斑狼疮(SLE)等自身免疫性疾病的胎儿肺动脉多普勒指标,干燥综合征（SS），以及健康孕妇的抗磷脂综合征（APS）。
方法：病例组包括39例妊娠，其中19个SLE，12与SS，八个带APS。将胎龄匹配的54例健康孕妇纳入对照组。收缩期峰值速度,时间平均速度，收缩压/舒张压比，搏动指数,阻力指数，加速时间(AT),喷射时间（ET），利用频谱多普勒超声从肺动脉波形获得AT/ET比值。
结果：在病例组中检测到明显较短的AT和较低的AT/ET比率（分别为p=<.001，p=<.001）。在APS组中，AT的缩短和AT/ET比值的降低更为明显。然而,SLE之间没有显着差异，SS,和APS组的胎儿肺动脉多普勒指数。此外，发现母体疾病持续时间(年)与胎儿肺动脉AT(r=-.516,p=.001)和AT/ET比值(r=-.558,p=<.001)之间存在中度相关性。
结论：母体自身免疫性疾病可能影响胎儿肺动脉多普勒指数。需要进一步的研究来评估胎儿肺多普勒指数，例如AT和AT/ET比值，以预测SLE孕妇的新生儿呼吸道发病率和肺成熟度。SS,和APS。
方法：病例组包括39例妊娠，其中19个SLE，12与SS，八个带APS。将胎龄匹配的54例健康孕妇纳入对照组。收缩期峰值速度,时间平均速度，收缩压/舒张压比，搏动指数,阻力指数，加速时间(AT),喷射时间（ET），利用频谱多普勒超声从肺动脉波形获得AT/ET比值。
结果：在病例组中检测到明显较短的AT和较低的AT/ET比率（分别为p=<.001，p=<.001）。在APS组中，AT的缩短和AT/ET比值的降低更为明显。然而,SLE之间没有显着差异，SS,和APS组的胎儿肺动脉多普勒指数。此外，发现母体疾病持续时间(年)与胎儿肺动脉AT(r=-.516,p=.001)和AT/ET比值(r=-.558,p=<.001)之间存在中度相关性。
结论：母体自身免疫性疾病可能影响胎儿肺动脉多普勒指数。需要进一步的研究来评估胎儿肺多普勒指数，例如AT和AT/ET比值，以预测SLE孕妇的新生儿呼吸道发病率和肺成熟度。SS,和APS。
