Participants completed US, BIS, and anthropometry immediately before and 1-2 h after HD for up to five sessions. US measured inferior vena cava (IVC) diameter, lung B-lines, muscle elastography, and dermal thickness. BIS measured the volume of extracellular (ECF) and intracellular (ICF) fluid. Anthropometry included mid-upper arm, calf and ankle circumferences, and triceps skinfold thickness. D2O was performed once pre-HD. We assessed the change in study measures pre- versus post-HD, and the correlation of change in study measures with percent change in body weight (%∆BW). We also assessed the agreement between TBW measured by BIS and D2O.
Eight participants aged 3.4-18.5 years were enrolled. Comparison of pre- and post-HD measures showed significant decrease in IVC diameters, lung B-lines, dermal thickness, BIS %ECF, mid-upper arm circumference, ankle, and calf circumference. Repeated measures correlation showed significant relationships between %∆BW and changes in BIS ECF (rrm =0.51, 95% CI 0.04, 0.80) and calf circumference (rrm=0.80, 95% CI 0.51, 0.92). BIS TBW correlated with D2O TBW but overestimated TBW by 2.2 L (95% LOA, -4.75 to 0.42).
BIS and calf circumference may be helpful to assess changes in fluid status in children receiving maintenance HD. IVC diameter, lung B-lines and dermal thickness are potential candidates for future studies.
方法:参与者完成了美国,BIS,在HD之前和之后1-2小时进行人体测量,最多可进行五次。美国测量下腔静脉(IVC)直径,肺B线,肌肉弹性成像,和真皮厚度。BIS测量细胞外(ECF)和细胞内(ICF)流体的体积。人体测量包括上臂中部,小腿和脚踝的围,和三头肌皮褶厚度。D2O在HD前进行一次。我们评估了HD前后研究指标的变化,以及研究指标变化与体重变化百分比(%ΔBW)的相关性。我们还评估了通过BIS和D2O测量的TBW之间的一致性。
结果:招募了8名年龄在3.4-18.5岁的参与者。比较前和后HD测量显示IVC直径显着下降,肺B线,真皮厚度,BIS%ECF,中上臂周长,脚踝,和小腿周长。重复测量相关性显示,BW%与BISECF(rrm=0.51,95%CI0.04,0.80)和小腿周长(rrm=0.80,95%CI0.51,0.92)的变化之间存在显著关系。BISTBW与D2OTBW相关,但高估了TBW2.2升(95%LOA,-4.75至0.42)。
结论:BIS和小腿围可能有助于评估接受维持性HD的儿童的体液状态变化。IVC直径,肺B线和真皮厚度是未来研究的潜在候选者.