Abstract：
A spinal cord injury (SCI) is a destructive event that causes a permanent deficit in neurological function because of poor regenerative potential. Transplantation therapies have attracted attention for restoration of the injured spinal cord, and transplantation of neural precursor cells (NPCs) has been studied worldwide. Several groups have demonstrated functional recovery via this therapeutic intervention due to the multiple beneficial effects of NPC transplantation, such as reconstruction of neuronal circuits, remyelination of axons, and neuroprotection by trophic factors. Our group developed a method to induce NPCs from human induced pluripotent stem cells (hiPSCs) and established a transplantation strategy for SCI. Functional improvement in SCI animals treated with hiPSC-NPCs was observed, and the safety of transplanting these cells was evaluated from multiple perspectives. With selection of a safe cell line and pretreatment of the cells to encourage maturation and differentiation, hiPSC-NPC transplantation therapy is now in the clinical phase of testing for subacute SCI. In addition, a research challenge will be to expand the efficacy of transplantation therapy for chronic SCI. More comprehensive strategies involving combination treatments are required to treat this problematic situation.
摘要：
脊髓损伤（SCI）是一种破坏性事件，由于再生潜力差，导致神经功能永久性缺陷。移植治疗引起了人们的关注，以恢复受损的脊髓，神经前体细胞（NPCs）的移植已在世界范围内进行了研究。由于NPC移植的多种有益作用，几个小组通过这种治疗干预已经证明了功能恢复。比如重建神经元回路，轴突髓鞘再生,和营养因子的神经保护作用。我们的团队开发了一种从人诱导多能干细胞（hiPSCs）诱导NPCs的方法，并建立了SCI的移植策略。观察到用hiPSC-NPC治疗的SCI动物的功能改善，并从多个角度评估移植这些细胞的安全性。选择安全的细胞系并预处理细胞以促进成熟和分化，hiPSC-NPC移植疗法目前处于亚急性SCI的临床测试阶段。此外,一项研究挑战将是扩大移植治疗慢性SCI的疗效.需要涉及联合治疗的更全面的策略来治疗这种有问题的情况。
