Abstract：
Propan-1,3-diol (PD) and propan-1,2-diol (propylene glycol, PG) are very similar compounds because their structures, safety data, and anti-microbial activities are almost the same. Actually, both compounds are made up of three carbon atoms and two hydroxyl groups. Regarding their safety, they do not have serious hazard data for animals, and LD50 values (in rats) of both are similar. As for the anti-microbial activity, minimum inhibitory concentration (MIC) values of both PD and PG are approximately 10% (v/v). In this study, we used the preservatives-effectiveness test (PET) to evaluate the anti-microbial activities of PD and PG, because both compounds are used in cosmetics as preservatives. The results indicated that PD was more effective as an anti-microbial agent compared with PG, and the effect of PD was marked against Escherichia coli and Pseudomonas aeruginosa. Scanning electron microscopy (SEM) images showed that the membrane of Escherichia coli was injured by PD and PG, but the damage by PD was more marked. The damage of the cell membrane may be the cause of high anti-microbial activity of PD in PET. These results suggest that PD has greater potential as a preservative, and PD should be recommended as an additive for food and medicine.
摘要：
1,3-丙二醇(PD)和1,2-丙二醇(丙二醇，PG)是非常相似的化合物，因为它们的结构，安全数据,和抗微生物活性几乎相同。事实上,这两种化合物都由三个碳原子和两个羟基组成。关于他们的安全,他们没有动物的严重危害数据，和LD50值(在大鼠中)相似。至于抗微生物活性，PD和PG的最小抑制浓度(MIC)值约为10%(v/v)。在这项研究中,我们使用防腐剂有效性试验（PET）来评估PD和PG的抗微生物活性，因为这两种化合物都在化妆品中用作防腐剂。结果表明，与PG相比，PD作为抗微生物剂更有效，PD对大肠杆菌和铜绿假单胞菌的作用明显。扫描电子显微镜(SEM)图像显示大肠杆菌的膜受到PD和PG的损伤,但PD造成的损害更为明显.细胞膜的损伤可能是PET中PD高抗微生物活性的原因。这些结果表明，PD作为防腐剂具有更大的潜力，和PD应推荐作为食品和药品的添加剂。
