Abstract：
BACKGROUND: In recent years, many clinical trials have used low-dose mifepristone to control uterine fibroids, some of which have achieved good results. However, according to the classic concept, long-term use of mifepristone could induce malignant transformation of the endometrium, and the effect of ultra-low-dose of mifepristone on uterine fibroids is still uncertain. Researchers are short on cases of uterine fibroids treated with mifepristone for long periods (more than a year).
METHODS: A 47-year-old woman went to the hospital because of anemia.
METHODS: The patient was diagnosed with uterine leiomyoma.
METHODS: The patient refused the suggestion of surgery, she was continuously treated with an ultra-low-dose (12.5 mg per 5 days) of mifepristone monotherapy for 4 years.
RESULTS: The uterine leiomyoma was stable, anemia and other symptoms disappeared, and the menstrual cycle, liver and kidney function, and tumor markers were normal.
CONCLUSIONS: Judging from our case, long-term, ultra-low-dose mifepristone for uterine fibroids treatment was safe and more effective than conventional therapy.
METHODS: A 47-year-old woman went to the hospital because of anemia.
METHODS: The patient was diagnosed with uterine leiomyoma.
METHODS: The patient refused the suggestion of surgery, she was continuously treated with an ultra-low-dose (12.5 mg per 5 days) of mifepristone monotherapy for 4 years.
RESULTS: The uterine leiomyoma was stable, anemia and other symptoms disappeared, and the menstrual cycle, liver and kidney function, and tumor markers were normal.
CONCLUSIONS: Judging from our case, long-term, ultra-low-dose mifepristone for uterine fibroids treatment was safe and more effective than conventional therapy.
摘要：
背景：近年来，许多临床试验使用低剂量米非司酮来控制子宫肌瘤，其中一些已经取得了良好的效果。然而,根据经典的概念，长期服用米非司酮可引起子宫内膜恶变,超低剂量米非司酮对子宫肌瘤的疗效尚不确定。研究人员缺乏长期使用米非司酮治疗的子宫肌瘤病例（超过一年）。
方法：一名47岁的妇女因贫血而去医院。
方法：患者诊断为子宫平滑肌瘤。
方法：患者拒绝手术建议，患者连续接受超低剂量(12.5mg/5日)米非司酮单药治疗4年.
结果：子宫平滑肌瘤稳定，贫血等症状消失,和月经周期，肝肾功能,肿瘤标志物正常.
结论：从我们的案例来看，长期的,超小剂量米非司酮治疗子宫肌瘤比常规治疗安全有效。
方法：一名47岁的妇女因贫血而去医院。
方法：患者诊断为子宫平滑肌瘤。
方法：患者拒绝手术建议，患者连续接受超低剂量(12.5mg/5日)米非司酮单药治疗4年.
结果：子宫平滑肌瘤稳定，贫血等症状消失,和月经周期，肝肾功能,肿瘤标志物正常.
结论：从我们的案例来看，长期的,超小剂量米非司酮治疗子宫肌瘤比常规治疗安全有效。
