Abstract：
Regardless of the progress made in the pathogenesis of ischemic stroke, it remains a leading cause of adult disability and death. To date, the most effective treatment for ischemic stroke is the timely recanalization of the occluded artery. However, the short time window and reperfusion injury have greatly limited its application and efficacy. Mitochondrial dysfunction and ATP depletion have become regarded as being hallmarks of neuropathophysiology following ischemic stroke. Mitochondrial transplantation is a novel potential therapeutic intervention for ischemic stroke that has sparked widespread concern during the past few years. This review summarizes and discusses the effects of mitochondrial transplantation in in vitro and in vivo ischemic stroke models. In addition, pharmacological interventions promoting mitochondrial transplantation are reviewed and discussed. We also discuss the potential challenges to the clinical application of mitochondrial transplantation in the treatment of ischemic stroke.
摘要：
无论在缺血性卒中的发病机制方面取得的进展，它仍然是成人残疾和死亡的主要原因。迄今为止,缺血性中风最有效的治疗方法是及时再通闭塞的动脉。然而,短的时间窗和再灌注损伤极大地限制了其应用和功效。线粒体功能障碍和ATP耗竭已被认为是缺血性中风后神经病理生理学的标志。线粒体移植是缺血性卒中的一种新的潜在治疗干预措施，在过去的几年中引起了广泛的关注。本文总结并讨论了线粒体移植在体外和体内缺血性中风模型中的作用。此外,综述和讨论了促进线粒体移植的药理干预措施。我们还讨论了线粒体移植在缺血性中风的临床应用中的潜在挑战。
