Abstract：
BACKGROUND: Overweight/obesity can affect fertility, increase the risk of pregnancy complications, and affect the outcome of assisted reproductive technology (ART). However, due to confounding factors, the accuracy and uniformity of published findings on IVF outcomes have been disputed. This study aimed to assess the effects of both male and female body mass index (BMI), individually and in combination, on IVF outcomes.
METHODS: This retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed.
RESULTS: Regarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p < 0.05); additionally, the fertilization (p < 0.001) and normal fertilization rates (p < 0.001) were significantly decreased in the female overweight/obesity group. The combined male/female overweight/obesity group had significant reductions in the available embryo (p = 0.002), high-quality embryo (p = 0.010), fertilization (p = 0.001) and normal fertilization rates (p < 0.001); however, neither male or female overweight/obesity nor their combination significantly affected the clinical pregnancy rate (CPR), live birth rate (LBR) or abortion rate (p > 0.05).
CONCLUSIONS: Our findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences.
METHODS: This retrospective cohort study included 11,191 couples undergoing IVF. Per the Chinese BMI standard, the couples were divided into four groups: normal; female overweight/obesity; male overweight/obesity; and combined male and female overweight/obesity. The IVF outcomes of the four groups were compared and analysed.
RESULTS: Regarding the 6569 first fresh IVF-ET cycles, compared with the normal weight group, the female overweight/obesity and combined male/female overweight/obesity groups had much lower numbers of available embryos and high-quality embryos (p < 0.05); additionally, the fertilization (p < 0.001) and normal fertilization rates (p < 0.001) were significantly decreased in the female overweight/obesity group. The combined male/female overweight/obesity group had significant reductions in the available embryo (p = 0.002), high-quality embryo (p = 0.010), fertilization (p = 0.001) and normal fertilization rates (p < 0.001); however, neither male or female overweight/obesity nor their combination significantly affected the clinical pregnancy rate (CPR), live birth rate (LBR) or abortion rate (p > 0.05).
CONCLUSIONS: Our findings support the notion that overweight/obesity does not influence pregnancy success; however, we found that overweight/obesity affects the fertilization rate and embryo number and that there are sex differences.
摘要：
背景：超重/肥胖会影响生育能力，增加妊娠并发症的风险，并影响辅助生殖技术（ART）的结局。然而,由于混杂因素，已发表的IVF结局研究结果的准确性和一致性存在争议.这项研究旨在评估男性和女性体重指数（BMI）的影响，单独和组合，IVF结果。
方法：这项回顾性队列研究包括11,191对接受IVF的夫妇。根据中国BMI标准，这些夫妇分为四组:正常;女性超重/肥胖;男性超重/肥胖;男女超重/肥胖组合.比较并分析四组的IVF结局。
结果：关于6569个首次新鲜IVF-ET周期，与正常体重组相比，女性超重/肥胖和男性/女性超重/肥胖组的可用胚胎和高质量胚胎数量低得多(p<0.05)；女性超重/肥胖组的受精率（p<0.001）和正常受精率（p<0.001）显着降低。男性/女性超重/肥胖组的可用胚胎显着减少（p=0.002），优质胚胎（p=0.010），受精（p=0.001）和正常受精率（p<0.001）；然而，男性或女性超重/肥胖或其组合均不会显着影响临床妊娠率（CPR），活产率(LBR)或流产率(p>0.05)。
结论：我们的研究结果支持超重/肥胖不影响妊娠成功的观点；然而，我们发现超重/肥胖会影响受精率和胚胎数量，并且存在性别差异。
方法：这项回顾性队列研究包括11,191对接受IVF的夫妇。根据中国BMI标准，这些夫妇分为四组:正常;女性超重/肥胖;男性超重/肥胖;男女超重/肥胖组合.比较并分析四组的IVF结局。
结果：关于6569个首次新鲜IVF-ET周期，与正常体重组相比，女性超重/肥胖和男性/女性超重/肥胖组的可用胚胎和高质量胚胎数量低得多(p<0.05)；女性超重/肥胖组的受精率（p<0.001）和正常受精率（p<0.001）显着降低。男性/女性超重/肥胖组的可用胚胎显着减少（p=0.002），优质胚胎（p=0.010），受精（p=0.001）和正常受精率（p<0.001）；然而，男性或女性超重/肥胖或其组合均不会显着影响临床妊娠率（CPR），活产率(LBR)或流产率(p>0.05)。
结论：我们的研究结果支持超重/肥胖不影响妊娠成功的观点；然而，我们发现超重/肥胖会影响受精率和胚胎数量，并且存在性别差异。
