PDF(Pubmed)
Abstract：
We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.
摘要：
我们报告了第四例描述的严重中毒性横纹肌溶解症病例，该病例发生在一名81岁女性中，原因是同时服用常规剂量（每天125mg）的帕博西尼和辛伐他汀。据我们所知,这是第一例成功通过血浆置换治疗的病例，在两个月内完成功能恢复。这种情况的严重程度证明了进一步考虑palbociclib或其他CDK-4-6抑制剂与他汀类药物之间的药代动力学相互作用，这可能会增加不良事件的风险。
