PDF(Pubmed)
Abstract：
Cryptococcal meningitis (CM) is a central nervous system disease caused by a novel Cryptococcus infection that leads to subacute or chronic inflammatory changes in the nervous system. In this study, we present the case of a woman aged 72 years with CM and severe cognitive impairment and disabilities. The cognitive assessment indicated that, although her cognitive function was impaired, especially executive function, it largely improved after receiving anti-infectious and repetitive transcranial magnetic stimulation, which can alter the membrane potential of the cortical nerve cells by triggering long-term potentiation and depression, modulating and releasing hormones, reducing the level of neuroinflammatory and peripheral blood cytokines, promoting nerve regeneration and synaptic remodeling, and changing the activity of the neural circuitry of the dorsolateral prefrontal cortex. We argue that this case provides a novel method of treatment for patients with CM in conjunction with cognitive impairments.
摘要：
隐球菌性脑膜炎（CM）是由新型隐球菌感染引起的中枢神经系统疾病，可导致神经系统的亚急性或慢性炎症变化。在这项研究中,我们介绍了一名女性的病例，该女性年龄72岁，患有严重的认知障碍和残疾。认知评估表明，尽管她的认知功能受损，尤其是执行功能，在接受抗感染和重复经颅磁刺激后，它可以通过引发长期增强和抑郁来改变皮质神经细胞的膜电位，调节和释放荷尔蒙，降低神经炎症和外周血细胞因子的水平，促进神经再生和突触重塑，并改变背外侧前额叶皮层神经回路的活动。我们认为，这种情况为CM合并认知障碍的患者提供了一种新颖的治疗方法。
