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Abstract：
Low physical activity (LPA) is associated with several major non-communicable diseases (NCDs) and premature mortality. In this study, we aimed to assess the global burden and trends in disease attributable to LPA (DALPA) from 1990 to 2019.
Annual age-standardized disability-adjusted life years (DALYs) and death rates of DALPA [all-cause and five specific causes (ischaemic heart disease, diabetes mellitus, stroke, colon and rectal cancer, and breast cancer)] by sex, age, geographical region and social deprivation index (SDI) score from 1990 to 2019 were available from the Global Burden of Disease (GBD) study 2019. The estimated annual percentage changes (EAPCs) were calculated to quantify the changing trend. A generalized linear model (GLM) was used to explore the relationship between DALYs/death rates of DALPA and sociodemographic factors.
Globally, in 2019, the age-standardized DALYs and death rates of DALPA were 198.42/100,000 (95% UI: 108.16/100,000-360.32/100,000) and 11.10/100,000 (95% UI: 5.66/100,000-19.51/100,000), respectively. There were 15.74 million (8.51-28.61) DALYs and 0.83 million (0.43-1.47) deaths attributable to LPA. Overall, age-standardized DALYs and death rates presented significant downward trends with EAPCs [-0.68% (95% CI: -0.85- -0.50%) for DALYs and -1.00% (95% CI: -1.13- -0.86%) for deaths] from 1990 to 2019. However, age-standardized DALYs and death rates of diabetes mellitus attributable to LPA were substantially increased [EAPC: 0.76% (95% CI: 0.70-0.82%) for DALYs and 0.33% (95% CI: 0.21-0.51%) for deaths]. In the 15-49 age group, DALPA presented significant upward trends [EAPC: 0.74% (95% CI: 0.58-0.91%) for DALYs and 0.31% (95% CI: 0.1-0.51%) for deaths]. The GLM revealed that higher gross domestic product and current health expenditure (% of GDP) were negatively associated with DALYs and death rates of DALPA.
Although global age-standardized DALYs and death rates of DALPA presented downward trends, they still cause a heavy burden worldwide. These rates showed upward trends in the diabetic and 15-49 age groups, which need more attention and health interventions.
Annual age-standardized disability-adjusted life years (DALYs) and death rates of DALPA [all-cause and five specific causes (ischaemic heart disease, diabetes mellitus, stroke, colon and rectal cancer, and breast cancer)] by sex, age, geographical region and social deprivation index (SDI) score from 1990 to 2019 were available from the Global Burden of Disease (GBD) study 2019. The estimated annual percentage changes (EAPCs) were calculated to quantify the changing trend. A generalized linear model (GLM) was used to explore the relationship between DALYs/death rates of DALPA and sociodemographic factors.
Globally, in 2019, the age-standardized DALYs and death rates of DALPA were 198.42/100,000 (95% UI: 108.16/100,000-360.32/100,000) and 11.10/100,000 (95% UI: 5.66/100,000-19.51/100,000), respectively. There were 15.74 million (8.51-28.61) DALYs and 0.83 million (0.43-1.47) deaths attributable to LPA. Overall, age-standardized DALYs and death rates presented significant downward trends with EAPCs [-0.68% (95% CI: -0.85- -0.50%) for DALYs and -1.00% (95% CI: -1.13- -0.86%) for deaths] from 1990 to 2019. However, age-standardized DALYs and death rates of diabetes mellitus attributable to LPA were substantially increased [EAPC: 0.76% (95% CI: 0.70-0.82%) for DALYs and 0.33% (95% CI: 0.21-0.51%) for deaths]. In the 15-49 age group, DALPA presented significant upward trends [EAPC: 0.74% (95% CI: 0.58-0.91%) for DALYs and 0.31% (95% CI: 0.1-0.51%) for deaths]. The GLM revealed that higher gross domestic product and current health expenditure (% of GDP) were negatively associated with DALYs and death rates of DALPA.
Although global age-standardized DALYs and death rates of DALPA presented downward trends, they still cause a heavy burden worldwide. These rates showed upward trends in the diabetic and 15-49 age groups, which need more attention and health interventions.
摘要：
未经证实：低体力活动（LPA）与几种主要的非传染性疾病（NCD）和过早死亡有关。在这项研究中,我们旨在评估1990年至2019年LPA(DALPA)引起的全球疾病负担和趋势.
未经评估：DALPA的年年龄标准化残疾调整寿命年（DALYs）和死亡率[全因和五个特定原因（缺血性心脏病，糖尿病,中风,结肠癌和直肠癌，和乳腺癌)]按性别划分，年龄,1990年至2019年的地理区域和社会剥夺指数(SDI)评分可从2019年全球疾病负担(GBD)研究获得.计算估计的年度百分比变化(EAPC)以量化变化趋势。使用广义线性模型（GLM）探讨DALYs/DALPA死亡率与社会人口统计学因素之间的关系。
未经评估：全球，2019年，DALPA的年龄标准化DALY和死亡率分别为198.42/100,000（95％UI：108.16/100,000-360.32/100,000）和11.10/100,000（95％UI：5.66/100,000-19.51/100,000），分别。LPA导致1574万（8.51-28.61）DALYs和83万（0.43-1.47）例死亡。总的来说,从1990年到2019年,年龄标准化的DALYs和死亡率呈现显著下降趋势,EAPCs[DALYs为-0.68%(95%CI:-0.85--0.50%),死亡为-1.00%(95%CI:-1.13--0.86%)].然而,年龄标准化的DALY和由LPA引起的糖尿病的死亡率显著增加[EAPC:DALY为0.76%(95%CI:0.70-0.82%),死亡为0.33%(95%CI:0.21-0.51%)].在15-49岁年龄段，DALPA呈现显著上升趋势[EAPC:DALYs为0.74%(95%CI:0.58-0.91%),死亡为0.31%(95%CI:0.1-0.51%)]。GLM显示，较高的国内生产总值和当前的卫生支出（占GDP的百分比）与DALPA的DALY和死亡率呈负相关。
未经评估：尽管全球年龄标准化的DALYs和DALPA的死亡率呈下降趋势，它们仍然在世界范围内造成沉重的负担。这些比率在糖尿病和15-49岁年龄组中呈上升趋势，这需要更多的关注和健康干预。
未经评估：DALPA的年年龄标准化残疾调整寿命年（DALYs）和死亡率[全因和五个特定原因（缺血性心脏病，糖尿病,中风,结肠癌和直肠癌，和乳腺癌)]按性别划分，年龄,1990年至2019年的地理区域和社会剥夺指数(SDI)评分可从2019年全球疾病负担(GBD)研究获得.计算估计的年度百分比变化(EAPC)以量化变化趋势。使用广义线性模型（GLM）探讨DALYs/DALPA死亡率与社会人口统计学因素之间的关系。
未经评估：全球，2019年，DALPA的年龄标准化DALY和死亡率分别为198.42/100,000（95％UI：108.16/100,000-360.32/100,000）和11.10/100,000（95％UI：5.66/100,000-19.51/100,000），分别。LPA导致1574万（8.51-28.61）DALYs和83万（0.43-1.47）例死亡。总的来说,从1990年到2019年,年龄标准化的DALYs和死亡率呈现显著下降趋势,EAPCs[DALYs为-0.68%(95%CI:-0.85--0.50%),死亡为-1.00%(95%CI:-1.13--0.86%)].然而,年龄标准化的DALY和由LPA引起的糖尿病的死亡率显著增加[EAPC:DALY为0.76%(95%CI:0.70-0.82%),死亡为0.33%(95%CI:0.21-0.51%)].在15-49岁年龄段，DALPA呈现显著上升趋势[EAPC:DALYs为0.74%(95%CI:0.58-0.91%),死亡为0.31%(95%CI:0.1-0.51%)]。GLM显示，较高的国内生产总值和当前的卫生支出（占GDP的百分比）与DALPA的DALY和死亡率呈负相关。
未经评估：尽管全球年龄标准化的DALYs和DALPA的死亡率呈下降趋势，它们仍然在世界范围内造成沉重的负担。这些比率在糖尿病和15-49岁年龄组中呈上升趋势，这需要更多的关注和健康干预。
