Osteochondrogenesis with Autologous Peripheral Blood Stem Cells for Osteochondral Lesions of the Talus: Report of Five Cases.

自体外周血干细胞治疗距骨软骨损伤 5 例.

• 发表时间: Nov 2022
• 来源期刊: Malays Orthop J
• DOI: 10.5704/MOJ.2211.019
• PMID: 36589370
• 文章类型: Case Reports
• 作者列表: Saw KY,Jee C,Ramlan A,Dawam A,Saw YC,Low SF

关键词: ankle osteoarthritis; marrow stimulation; osteochondral lesions of the talus; osteochondrogenesis; peripheral blood stem cells

Abstract

Osteochondral lesions of the talus (OLTs) may progress to ankle arthritis needing ankle arthroplasty or arthrodesis. We report five cases of OLTs treated along the principles developed for chondrogenesis of the knee joint with autologous peripheral blood stem cells (PBSCs), resulting in repair and regeneration of the bone and cartilage components. Improvement in Ankle Osteoarthritis Scale (AOS) scores with minimum two years follow-up showed statistical significance (p < 0.05).

摘要

距骨软骨损伤（OLTs）可能会发展为需要进行踝关节成形术或关节固定术的踝关节炎。我们报告了5例OLTs按照自体外周血干细胞（PBSCs）用于膝关节软骨形成的原则进行治疗。导致骨和软骨成分的修复和再生。踝关节骨性关节炎量表(AOS)评分的改善与最低2年随访有统计学意义(p<0.05)。