UNASSIGNED: We utilized standardized autonomic nervous system (ANS) reflex assessment and wireless motility capsule testing to evaluate 20 individuals with idiopathic autonomic neuropathy and unexplained gastrointestinal symptoms. Additionally, we examined the relationship between quantifiable autonomic neuropathy and gastrointestinal dysmotility at specific neuroanatomical levels. Symptom profiles were evaluated using the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS-31) and compared to wireless motility capsule data.
UNASSIGNED: We found that transit times were predominately abnormal (delayed) in the foregut (10 of 20; 50%), while contractility abnormalities were far more prominent in the hindgut (17 of 20; 85%), and that motility and symptom patterns, as assessed by the COMPASS-31 GI domain items, generally corresponded. Finally, we also found that there was neuroanatomical overlap in the presence of autonomic reflex abnormalities and WMC-based transit and/or contractility abnormalities.
UNASSIGNED: We found that transit times were predominately abnormal in the foregut and midgut, while contractility abnormalities were far more prominent in the hindgut in individuals with idiopathic autonomic neuropathy. There was a high rate of agreement in segmental wireless motility capsule data with neuroanatomically corresponding standardized ANS function measures (e.g., cardiovagal, sudomotor, adrenergic). Expanded sudomotor testing, including additional neuroanatomical segments, could provide additional indirect assessment of visceral involvement in ANS dysfunction.
UNASSIGNED:我们使用标准化的自主神经系统(ANS)反射评估和无线运动胶囊测试来评估20例特发性自主神经病变和无法解释的胃肠道症状的个体。此外,我们在特定的神经解剖学水平研究了可量化的自主神经病变与胃肠动力障碍之间的关系.使用31项复合自主症状评分问卷(COMPASS-31)评估症状,并与无线运动胶囊数据进行比较。
UNASSIGNED:我们发现,运输时间在前肠中主要是异常的(延迟的)(20个中的10个;50%),而收缩异常在后肠中更为突出(20个中的17个;85%),以及运动性和症状模式,根据COMPASS-31GI域项目的评估,大致对应。最后,我们还发现,在存在自主神经反射异常和基于WMC的转运和/或收缩异常时,存在神经解剖学重叠.
未经证实:我们发现,在前肠和中肠的运输时间主要是异常的,而收缩异常在特发性自主神经病变患者的后肠更为明显。分段无线运动胶囊数据与神经解剖学上相应的标准化ANS功能测量的一致性很高(例如,心迷走神经,sudomotor,肾上腺素能)。扩展的sudomotor测试,包括额外的神经解剖部分,可以提供对ANS功能障碍的内脏受累的额外间接评估。