Abstract：
Mucosal-associated invariant T (MAIT) cells are a subset of innate T lymphocytes that express the semi-invariant T cell receptor and recognize riboflavin metabolites via the major histocompatibility complex class I-related protein. Given the abundance of MAIT cells in the human body, their role in human diseases has been increasingly studied in recent years. MAIT cells may serve as targets for clinical therapy. Specifically, this review discusses how MAIT cells are altered in gastric, esophageal, intestinal, and hepatobiliary diseases and describes their protective or pathogenic roles. A greater understanding of MAIT cells will provide a more favorable therapeutic approach for digestive diseases in the clinical field.
摘要：
粘膜相关的不变T（MAIT）细胞是先天性T淋巴细胞的子集，其表达半不变T细胞受体（TCR）并通过主要的组织相容性复合物I类相关蛋白（MR1）识别核黄素代谢物。鉴于人体内有丰富的MAIT细胞，近年来，它们在人类疾病中的作用得到了越来越多的研究。MAIT细胞可作为临床治疗的靶标。具体来说,这篇综述讨论了MAIT细胞如何在胃中改变，食道,肠和肝胆疾病，并描述了它们的保护或致病作用。对MAIT细胞的更深入了解将为临床领域的消化系统疾病提供更有利的治疗方法。
