Abstract：
Esophageal dysmotility in esophageal atresia (EA) relates to abnormal development of esophageal innervation and musculature and to the esophageal repair. Few studies have investigated the preexisting dysmotility in EA, present prior to surgery. This systematic review aims to summarize the literature on neuronal studies in EA, to understand the causative factors for esophageal dysmotility. We performed a systematic review (PubMed, EMBASE, EBM, CINAHL databases; January 1947-February 2021) in accordance with PRISMA (PROSPERO number CRD42020171014). Fourteen studies were identified (eleven human, 187 EA patients; three animal, 64 EA rat specimens). Neural factors affecting esophageal dysmotility in human and animal studies included proteins, enzymes, growth factors, and genes, which play a role in the nervous system or neuroendocrine system, some of which have functions as neuromodulators or neurotransmitters. This systematic review has identified neural factors that affect esophageal dysmotility and contributes toward our understanding of the underlying dysmotility in patients with EA. The studies identified are important and essential for successful translation of basic science knowledge to impact clinical practice and understanding. Level of evidence: III.
摘要：
食管闭锁（EA）的食管运动障碍与食管神经支配和肌肉组织的异常发育以及食管修复有关。很少有研究调查EA中预先存在的运动障碍，在手术前。这篇系统的综述旨在总结EA中神经元研究的文献，了解食管运动障碍的致病因素。我们进行了系统回顾(PubMed，EMBASE,EBM,CINAHL数据库；1947年1月至2021年2月）符合PRISMA（PROSPERO编号CRD42020171014）。确定了14项研究（11项人类，187例EA患者；三只动物，64例EA大鼠标本)。在人类和动物研究中影响食道运动障碍的神经因素包括蛋白质，酶，生长因子，和基因，在神经系统或神经内分泌系统中发挥作用，其中一些具有神经调质或神经递质的功能。这项系统评价已经确定了影响食管运动障碍的神经因素，并有助于我们了解EA患者的潜在运动障碍。确定的研究对于成功翻译基础科学知识以影响临床实践和理解至关重要。证据等级：III.
