PDF(Pubmed)
Abstract：
This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. The family consists of a mother, father, son, and daughter. The mother experienced issues with focus, memory, anger, and amotivational syndrome. The father experienced weight issues and depression. The son experienced heavy drinking, along with some drug abuse and anxiety. The daughter experienced depression, lethargy, brain fog, focus issues, and anxiety, among others. A major clinical outcome of the results presented to the family members helped reduce personal guilt and augment potential hope for future healing. Our laboratory\'s prior research established that carriers of four or more alleles measured by GARS (DRD1-DRD4, DAT1, MOR, GABABR3, COMT, MAOAA, and 5HTLPR) are predictive of the addiction severity index (ASI) for drug abuse, and carriers of seven or more alleles are predictive of severe alcoholism. This generational case series shows the impact that genetic information has on reducing stigma and guilt in a nuclear family struggling with RDS behaviors. The futuristic plan is to introduce an appropriate DNA-guided \"pro-dopamine regulator\" into the recovery and enhancement of life.
摘要：
这个案例系列介绍了新的遗传成瘾风险评分(GARS)，这表明，在具有表达低多巴胺能先例的多重奖励缺乏综合征（RDS）行为问题的核心家庭中，奖励基因的多态性风险等位基因的患病率很高。家庭由母亲组成，父亲,儿子,和女儿。这位母亲专注地经历了问题，记忆,愤怒,和兴奋综合征。父亲经历了体重问题和抑郁症。儿子经历了大量饮酒，还有一些药物滥用和焦虑。女儿经历了抑郁症，嗜睡,脑雾,焦点问题,和焦虑，在其他人中。向家庭成员展示的结果的主要临床结果有助于减少个人的罪恶感，并增加对未来康复的潜在希望。我们实验室的先前研究确定，通过GARS（DRD1-DRD4，DAT1，MOR，GABABR3,COMT,MAOAA,和5HTLPR)是药物滥用成瘾严重程度指数(ASI)的预测指标，七个或更多等位基因的携带者可以预测严重的酒精中毒。这个世代案例系列显示了遗传信息对减少与RDS行为作斗争的核心家庭中的污名和罪恶感的影响。未来的计划是将适当的DNA指导的“促多巴胺调节剂”引入生命的恢复和增强。
