PDF(Pubmed)
Abstract：
UNASSIGNED: Multiple sclerosis (MS) is recognized as the most prevalent autoimmune abnormality of the CNS. T1WI, T2WI, and FLAIR are limited in the quantification of tissue damage and detection of tissue alterations in white and grey matter in MS. This study aimed to the evaluation of changes in DTI indices in these patients at the thalamus and basal ganglia.
UNASSIGNED: 30 relapsing-remitting MS (RRMS) cases and 30 normal individuals were included. Conventional MRI (T2, FLAIR) was acquired to confirm NAGM in MS patients. A T1 MPRAGE protocol was used to normalize DTI images. FSL, SPM, and Explore DTI software were employed to reach Mean Diffusivities (MD), Axial Diffusivities (AD), Fractional anisotropy (FA), and Radial Diffusivity (RD) at the thalamus and the basal ganglia.
UNASSIGNED: The FA and RD of the thalamus were decreased in healthy controls compared to MS cases (0.319 vs. 0.296 and 0.0009 vs. 0.0006, respectively) (P < 0.05). The AD value in the thalamus and the FA value in the caudate nucleus were significantly lower in MS cases than in controls (0.0009 vs. 0.0011 and 0.16 vs. 0.18, respectively) (P < 0.05). MD values in the thalamus or basal ganglia were not significantly different between groups.
UNASSIGNED: DTI measures including FA, RD, and AD have a good diagnostic performance in detecting microstructural changes in the normal-appearing thalamus in cases with RRMS while they had no significant relationship with clinical signs in terms of EDSS.
UNASSIGNED: Not applicable.
UNASSIGNED: 30 relapsing-remitting MS (RRMS) cases and 30 normal individuals were included. Conventional MRI (T2, FLAIR) was acquired to confirm NAGM in MS patients. A T1 MPRAGE protocol was used to normalize DTI images. FSL, SPM, and Explore DTI software were employed to reach Mean Diffusivities (MD), Axial Diffusivities (AD), Fractional anisotropy (FA), and Radial Diffusivity (RD) at the thalamus and the basal ganglia.
UNASSIGNED: The FA and RD of the thalamus were decreased in healthy controls compared to MS cases (0.319 vs. 0.296 and 0.0009 vs. 0.0006, respectively) (P < 0.05). The AD value in the thalamus and the FA value in the caudate nucleus were significantly lower in MS cases than in controls (0.0009 vs. 0.0011 and 0.16 vs. 0.18, respectively) (P < 0.05). MD values in the thalamus or basal ganglia were not significantly different between groups.
UNASSIGNED: DTI measures including FA, RD, and AD have a good diagnostic performance in detecting microstructural changes in the normal-appearing thalamus in cases with RRMS while they had no significant relationship with clinical signs in terms of EDSS.
UNASSIGNED: Not applicable.
摘要：
未经证实：多发性硬化症（MS）被认为是中枢神经系统最普遍的自身免疫异常。T1WI,T2WI,和FLAIR在定量组织损伤和检测MS白质和灰质组织改变方面受到限制。本研究旨在评估这些患者丘脑和基底节DTI指数的变化。
未经证实：纳入30例复发缓解型MS（RRMS）病例和30例正常人。获得常规MRI（T2，FLAIR）以确认MS患者的NAGM。使用T1MPRAGE协议对DTI图像进行归一化。FSL,SPM,采用ExploreDTI软件达到平均扩散率(MD)，轴向扩散率（AD），分数各向异性（FA），丘脑和基底神经节的径向扩散系数（RD）。
UNASSIGNED：与MS病例相比，健康对照组的丘脑FA和RD降低（0.319vs.0.296和0.0009vs.分别为0.0006)(P<0.05)。MS病例的丘脑AD值和尾状核FA值明显低于对照组（0.0009vs.0.0011和0.16vs.分别为0.18）（P<0.05）。丘脑或基底神经节的MD值在组间没有显着差异。
未经评估：DTI措施，包括FA，RD,在RRMS病例中，AD在检测正常丘脑的微观结构变化方面具有良好的诊断性能，而就EDSS而言，它们与临床体征没有显着关系。
UNASSIGNED：不适用。
未经证实：纳入30例复发缓解型MS（RRMS）病例和30例正常人。获得常规MRI（T2，FLAIR）以确认MS患者的NAGM。使用T1MPRAGE协议对DTI图像进行归一化。FSL,SPM,采用ExploreDTI软件达到平均扩散率(MD)，轴向扩散率（AD），分数各向异性（FA），丘脑和基底神经节的径向扩散系数（RD）。
UNASSIGNED：与MS病例相比，健康对照组的丘脑FA和RD降低（0.319vs.0.296和0.0009vs.分别为0.0006)(P<0.05)。MS病例的丘脑AD值和尾状核FA值明显低于对照组（0.0009vs.0.0011和0.16vs.分别为0.18）（P<0.05）。丘脑或基底神经节的MD值在组间没有显着差异。
未经评估：DTI措施，包括FA，RD,在RRMS病例中，AD在检测正常丘脑的微观结构变化方面具有良好的诊断性能，而就EDSS而言，它们与临床体征没有显着关系。
UNASSIGNED：不适用。
