PDF(Pubmed)
Abstract：
Diabetes mellitus has become a global health problem, and the number of patients with diabetic foot ulcers (DFU) is rapidly increasing. Currently, DFU still poses great challenges to physicians, as the treatment is complex, with high risks of infection, recurrence, limb amputation, and even death. Therefore, a comprehensive understanding of DFU pathogenesis is of great importance. In this review, we summarized recent findings regarding the DFU development from the perspective of single-nucleotide variations (SNVs). Studies have shown that SNVs located in the genes encoding C-reactive protein, interleukin-6, tumor necrosis factor-alpha, stromal cell-derived factor-1, vascular endothelial growth factor, nuclear factor erythroid-2-related factor 2, sirtuin 1, intercellular adhesion molecule 1, monocyte chemoattractant protein-1, endothelial nitric oxide synthase, heat shock protein 70, hypoxia inducible factor 1 alpha, lysyl oxidase, intelectin 1, mitogen-activated protein kinase 14, toll-like receptors, osteoprotegerin, vitamin D receptor, and fibrinogen may be associated with the development of DFU. However, considering the limitations of the present investigations, future multi-center studies with larger sample sizes, as well as in-depth mechanistic research are warranted.
摘要：
糖尿病已成为全球性的健康问题,糖尿病足溃疡(DFU)患者数量迅速增加。目前,DFU仍然对医生构成巨大挑战，由于治疗复杂，有很高的感染风险，复发,截肢,甚至死亡。因此,全面了解DFU的发病机制具有重要意义。在这次审查中,我们从单核苷酸变异（SNV）的角度总结了有关DFU发展的最新发现。研究表明,SNVs位于编码C反应蛋白的基因中,白细胞介素-6,肿瘤坏死因子-α,基质细胞衍生因子-1,血管内皮生长因子,核因子-2相关因子2,沉默酶1,细胞间粘附分子1,单核细胞趋化蛋白-1,内皮型一氧化氮合酶,热休克蛋白70,缺氧诱导因子1α,赖氨酰氧化酶，内皮素1，丝裂原活化蛋白激酶14，toll样受体，骨保护素,维生素D受体，纤维蛋白原可能与DFU的发生发展有关。然而,考虑到目前调查的局限性，未来具有更大样本量的多中心研究，以及深入的机械研究是必要的。
