Abstract：
Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades. The pharmaceutical value of dicoumarol turned it into a focus of chemists\' attention, aiming its synthesis and of dicoumarol derivatives, bringing to light new methodologies. In recent years, several other bioactive effects have been claimed for dicoumarol and its derivatives, including anti-inflammatory, antimicrobial, antifungal, and anticancer, although the mechanisms of action underlying them are mostly not disclosed and additional research is needed to unravel them. This review presents a state of the art on the chemistry of dicoumarols, and their potential anticancer characteristics, highlighting the mechanisms of action elucidated so far. In parallel, we draw attention to the lack of in vivo studies and clinical trials to assess the safety and efficacy as drugs for later application.
摘要：
Dicoumarol,一种类似香豆素的化合物,以其与抑制维生素K的能力相关的抗凝血特性而闻名，几十年来一直被处方为药物。双香豆酚的药用价值使其成为化学家关注的焦点，针对其合成和双香豆酚衍生物，带来新的方法。近年来,双香豆酚及其衍生物的其他几种生物活性作用已被声称，包括消炎药,抗菌，抗真菌药,和抗癌，尽管它们背后的作用机制大多没有公开，需要更多的研究来解开它们。这篇综述介绍了双香丸化学的最新技术，以及它们潜在的抗癌特性，强调迄今为止阐明的行动机制。并行,我们提请注意缺乏体内研究和临床试验来评估作为药物的安全性和有效性以供以后应用.
