Abstract：
BACKGROUND: Although many biomarkers for lung adenocarcinoma (LUAD) have been identified, their specificity and sensitivity remain unsatisfactory. Endothelial lipase gene (LIPG) plays an important role in a variety of cancers, but its role in lung adenocarcinoma remains unclear.
METHODS: TCGA, GEO, K-M plotter, CIBERSORT, GSEA, HPA, and GDSC were used to analyze LIPG in LUAD. Data analysis was mainly achieved by R 4.0.3.
RESULTS: The expression of LIPG in LUAD tissues was higher than that in adjacent normal tissues, especially in women, patients aged >65 years, and those with lymph node metastasis. High expression predicted a poor prognosis. The results of enrichment analysis suggest that LIPG may exert profound effects on the development of LUAD through multiple stages of lipid metabolism and immune system regulation. In addition, LIPG expression was significantly correlated with the expression levels of multiple immune checkpoint genes and the abundance of multiple immune infiltrates, including the activated memory CD4 T cell, M1 macrophage, neutrophil, plasma cells, and T follicular helper (Tfh) cells in the LUAD microenvironment content. At the same time, patients with high LIPG expression respond well to a variety of antitumor drugs and have a low rate of drug resistance.
CONCLUSIONS: LIPG is a prognostic marker and is associated with lipid metabolism and immune infiltration in LUAD.
METHODS: TCGA, GEO, K-M plotter, CIBERSORT, GSEA, HPA, and GDSC were used to analyze LIPG in LUAD. Data analysis was mainly achieved by R 4.0.3.
RESULTS: The expression of LIPG in LUAD tissues was higher than that in adjacent normal tissues, especially in women, patients aged >65 years, and those with lymph node metastasis. High expression predicted a poor prognosis. The results of enrichment analysis suggest that LIPG may exert profound effects on the development of LUAD through multiple stages of lipid metabolism and immune system regulation. In addition, LIPG expression was significantly correlated with the expression levels of multiple immune checkpoint genes and the abundance of multiple immune infiltrates, including the activated memory CD4 T cell, M1 macrophage, neutrophil, plasma cells, and T follicular helper (Tfh) cells in the LUAD microenvironment content. At the same time, patients with high LIPG expression respond well to a variety of antitumor drugs and have a low rate of drug resistance.
CONCLUSIONS: LIPG is a prognostic marker and is associated with lipid metabolism and immune infiltration in LUAD.
摘要：
背景：尽管已经确定了许多肺腺癌（LUAD）的生物标志物，其特异性和敏感性仍不能令人满意.内皮脂肪酶基因(LIPG)在多种肿瘤中发挥着重要作用,但其在肺腺癌中的作用尚不清楚。
方法：TCGA，GEO,K-M绘图仪,CIBERSORT,GSEA,HPA,用GDSC分析LUAD中的LIPG。数据分析主要由R4.0.3实现。
结果：LIPG在LUAD组织中的表达高于癌旁正常组织，尤其是女性,年龄>65岁的患者，还有那些有淋巴结转移的.高表达预测不良预后。富集分析结果表明，LIPG可能通过脂质代谢和免疫系统调节的多个阶段对LUAD的发生发展产生深远的影响。此外,LIPG的表达与多种免疫检查点基因的表达水平和多种免疫浸润物的丰度显著相关,包括激活的记忆CD4T细胞，M1巨噬细胞，中性粒细胞,浆细胞,和T滤泡辅助（Tfh）细胞在LUAD微环境中的含量。同时,LIPG高表达患者对多种抗肿瘤药物反应良好,耐药率低。
结论：LIPG是一种预后标志物，与LUAD的脂质代谢和免疫浸润有关。
方法：TCGA，GEO,K-M绘图仪,CIBERSORT,GSEA,HPA,用GDSC分析LUAD中的LIPG。数据分析主要由R4.0.3实现。
结果：LIPG在LUAD组织中的表达高于癌旁正常组织，尤其是女性,年龄>65岁的患者，还有那些有淋巴结转移的.高表达预测不良预后。富集分析结果表明，LIPG可能通过脂质代谢和免疫系统调节的多个阶段对LUAD的发生发展产生深远的影响。此外,LIPG的表达与多种免疫检查点基因的表达水平和多种免疫浸润物的丰度显著相关,包括激活的记忆CD4T细胞，M1巨噬细胞，中性粒细胞,浆细胞,和T滤泡辅助（Tfh）细胞在LUAD微环境中的含量。同时,LIPG高表达患者对多种抗肿瘤药物反应良好,耐药率低。
结论：LIPG是一种预后标志物，与LUAD的脂质代谢和免疫浸润有关。
