PDF(Pubmed)
Abstract：
The human papillomavirus (HPV) is a non-enveloped DNA virus that causes a variety of skin and mucosal lesions. This report reviews a likely HPV-related lesion of oral squamous cell papilloma clinically mimicking oral verrucous leukoplakia. A 71-year-old white male presented with a raised white lesion on the palatal mucosa. It felt hard on palpation and had a sessile fixed base, and a rough verrucous surface. The lesion was fully excised. Histopathology showed short, thin, fingerlike projections lined by stratified squamous epithelium with thin central connective tissue cores. The epithelial superficial layers demonstrated focal koilocytotic changes suggestive of an HPV infection. High-risk HPV-related lesions have the potential to turn malignant. Early diagnosis and management are critical to preventing serious complications.
摘要：
人乳头瘤病毒（HPV）是一种无包膜DNA病毒，可引起多种皮肤和粘膜病变。该报告回顾了临床上模仿口腔疣状白斑的口腔鳞状细胞乳头状瘤的可能的HPV相关病变。一名71岁的白人男性在pal粘膜上出现白色病变。触诊时感觉很硬，有一个固定的底座，和粗糙的疣状表面。病变被完全切除。组织病理学显示短，薄,指状突起由分层鳞状上皮衬有薄的中央结缔组织核心。上皮浅层表现出提示HPV感染的局灶性肾细胞变化。高危型HPV相关病变有可能变成恶性。早期诊断和管理对于预防严重并发症至关重要。
