PDF(Pubmed)
Abstract：
BACKGROUND: Multiple myeloma (MM) can be accompanied by amyloidosis, which occurs in a small number of patients and is characterized by deposition of light chains in the joints, leading to multiple myeloma-associated amyloid arthropathy (MAA). As a rare complication of MM, clinical manifestations of MAA are often similar to those of rheumatoid arthritis, and the two are easily confused.
METHODS: In recent years, our center treated two patients of MM with amyloid arthropathy as the first manifestation, both of whom presented with polyarthritis. After treatment for MM, both patients achieved complete remission. However, subsequently, the two patients underwent hip arthroplasty for femoral neck fractures. Congo red staining and immunofluorescence of the joint tissues confirmed MAA after surgery. Eventually, one of the patients died of MM recurrence, while the other survived.
CONCLUSIONS: MAA should be regarded as an initial symptom of MM and should be taken seriously.
METHODS: In recent years, our center treated two patients of MM with amyloid arthropathy as the first manifestation, both of whom presented with polyarthritis. After treatment for MM, both patients achieved complete remission. However, subsequently, the two patients underwent hip arthroplasty for femoral neck fractures. Congo red staining and immunofluorescence of the joint tissues confirmed MAA after surgery. Eventually, one of the patients died of MM recurrence, while the other survived.
CONCLUSIONS: MAA should be regarded as an initial symptom of MM and should be taken seriously.
摘要：
背景：多发性骨髓瘤（MM）可伴有淀粉样变性，发生在少数患者中，其特征是轻链在关节中沉积，导致多发性骨髓瘤相关淀粉样关节病（MAA）。作为MM的罕见并发症，MAA的临床表现通常与类风湿性关节炎相似，两者很容易混淆。
方法：近年来，我们中心收治了两名以淀粉样关节炎为首发表现的MM患者，两人都患有多关节炎。MM治疗后，两名患者均达到完全缓解.然而,随后,2例股骨颈骨折患者行髋关节置换术。术后关节组织刚果红染色和免疫荧光证实MAA。最终,其中一名患者死于MM复发,而另一个幸存下来。
结论：MAA应视为MM的初始症状，应认真对待。
方法：近年来，我们中心收治了两名以淀粉样关节炎为首发表现的MM患者，两人都患有多关节炎。MM治疗后，两名患者均达到完全缓解.然而,随后,2例股骨颈骨折患者行髋关节置换术。术后关节组织刚果红染色和免疫荧光证实MAA。最终,其中一名患者死于MM复发,而另一个幸存下来。
结论：MAA应视为MM的初始症状，应认真对待。
