关键词: Depressive symptoms High-frequency Motor symptoms Non-motor symptoms Parkinson’s disease Quality of life Repetitive transcranial magnetic stimulation

来  源:   DOI:10.1016/j.heliyon.2022.e12196   PDF(Pubmed)

Abstract:
UNASSIGNED: Parkinson\'s disease (PD) is a common neurodegenerative disorder, characterised by both motor and nonmotor symptoms. There is currently no cure for PD, although there are several treatment options for relieving PD symptoms. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation therapy that shows promising results for the treatment of PD.
UNASSIGNED: Here, we present a patient with PD. We investigated whether an accelerate form of high-frequency (HF) rTMS on the contralateral side to the patient\'s main difficulties is clinically effective in treating health-related quality of life (QoL) symptomatology and depressive symptoms in PD as well as the long-term effects of rTMS in PD during the maintenance phase.
UNASSIGNED: Results showed that HF-rTMS administered over the right primary motor cortex (M1) is a safe and well-tolerated treatment that improved the patient\'s health related QoL and depressive symptoms. These positive effects lasted at least five months post treatment.
UNASSIGNED: Therefore, HF-rTMS over the right M1 can be a possible treatment option for patients with PD, although further investigations are necessary to validate the findings of the present case report.
摘要:
未经证实:帕金森病(PD)是一种常见的神经退行性疾病,表现为运动和非运动症状。目前没有治愈PD的方法,虽然有几种治疗方案可以缓解PD症状。重复经颅磁刺激(rTMS)是一种无创的脑刺激疗法,对PD的治疗显示出有希望的结果。
未经评估:这里,我们介绍了一名PD患者。我们调查了在患者主要困难的对侧加速形式的高频(HF)rTMS是否在临床上有效治疗与健康相关的生活质量(QoL)症状和抑郁症状,以及在维持阶段rTMS在PD中的长期影响。
UNASSIGNED:结果显示,在右初级运动皮质(M1)上给予HF-rTMS是一种安全且耐受性良好的治疗方法,可改善患者的健康相关QoL和抑郁症状。这些积极作用在治疗后持续至少5个月。
UNASSIGNED:因此,HF-rTMS超过右侧M1可能是PD患者的可能治疗选择,尽管需要进一步调查以验证本病例报告的发现。
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