Abstract：
OBJECTIVE: The study aims to observe the spontaneous remission of posterior vitreous detachment (PVD)-type vision degrading myodesopsia (VDM) during long-term follow-up.
METHODS: We retrospectively reviewed VDM patients with PVD type that refused any treatment. The ratio and time of significant spontaneous remission of floater symptoms occurring were described. The associated factors with significant remission of floater symptoms were analyzed in the univariate and multivariate logistic regression analyses.
RESULTS: In total, 179 patients with VDM were assessed. The mean age of all patients was 60.56 ± 0.47 years old, and the mean duration of follow-up was 23.89 ± 6.63 months. Of the patients, 40.78% have significant improvement in their floater symptoms after mean 16.55 ± 10.63-month follow-up. Myopia (OR = 0.280, 95% CI = 0.084-0.932, P = 0.038), the number of floaters > 3 (OR = 0.343, 95% CI = 0.172-0.683, P = 0.002), and floaters with string-like pattern (OR = 0.370, 95% CI = 0.166-0.824, P = 0.015) and blocky pattern (OR = 0.299, 95% CI = 0.090-0.993, P = 0.049) were negatively correlated with the significant spontaneous remission of VDM symptoms in the multiple binary logistic regression analysis.
CONCLUSIONS: Approximately 40% of VDM patients with PVD may experience significant spontaneous remission during long-term follow-up. Patients that are non-myopic and with fewer floaters are more likely to feel relief from VDM symptoms. Floaters with string-like or blocky patterns are less likely to undergo spontaneous remission.
METHODS: We retrospectively reviewed VDM patients with PVD type that refused any treatment. The ratio and time of significant spontaneous remission of floater symptoms occurring were described. The associated factors with significant remission of floater symptoms were analyzed in the univariate and multivariate logistic regression analyses.
RESULTS: In total, 179 patients with VDM were assessed. The mean age of all patients was 60.56 ± 0.47 years old, and the mean duration of follow-up was 23.89 ± 6.63 months. Of the patients, 40.78% have significant improvement in their floater symptoms after mean 16.55 ± 10.63-month follow-up. Myopia (OR = 0.280, 95% CI = 0.084-0.932, P = 0.038), the number of floaters > 3 (OR = 0.343, 95% CI = 0.172-0.683, P = 0.002), and floaters with string-like pattern (OR = 0.370, 95% CI = 0.166-0.824, P = 0.015) and blocky pattern (OR = 0.299, 95% CI = 0.090-0.993, P = 0.049) were negatively correlated with the significant spontaneous remission of VDM symptoms in the multiple binary logistic regression analysis.
CONCLUSIONS: Approximately 40% of VDM patients with PVD may experience significant spontaneous remission during long-term follow-up. Patients that are non-myopic and with fewer floaters are more likely to feel relief from VDM symptoms. Floaters with string-like or blocky patterns are less likely to undergo spontaneous remission.
摘要：
目的：本研究旨在观察长期随访中玻璃体后脱离（PVD）型视力下降肌营养不良（VDM）的自发缓解情况。
方法：我们回顾性分析了拒绝任何治疗的PVD型VDM患者。描述了浮子症状发生的显着自发缓解的比例和时间。在单因素和多因素logistic回归分析中分析了漂浮物症状显着缓解的相关因素。
结果：总计，对179例VDM患者进行了评估。所有患者的平均年龄为60.56±0.47岁,平均随访时间为23.89±6.63个月。在患者中，平均随访16.55±10.63个月后，有40.78％的漂浮物症状明显改善。近视(OR=0.280,95%CI=0.084-0.932,P=0.038),漂浮物数>3(OR=0.343,95%CI=0.172-0.683,P=0.002),在多元二元逻辑回归分析中，具有串状模式（OR=0.370，95％CI=0.166-0.824，P=0.015）和块状模式（OR=0.299，95％CI=0.090-0.993，P=0.049）的漂浮物与VDM症状的显着自发缓解呈负相关。
结论：约40%的VDM伴PVD患者在长期随访期间可能经历显著的自发缓解。非近视性和较少漂浮物的患者更有可能感到VDM症状缓解。具有线状或块状图案的漂浮物不太可能自发缓解。
方法：我们回顾性分析了拒绝任何治疗的PVD型VDM患者。描述了浮子症状发生的显着自发缓解的比例和时间。在单因素和多因素logistic回归分析中分析了漂浮物症状显着缓解的相关因素。
结果：总计，对179例VDM患者进行了评估。所有患者的平均年龄为60.56±0.47岁,平均随访时间为23.89±6.63个月。在患者中，平均随访16.55±10.63个月后，有40.78％的漂浮物症状明显改善。近视(OR=0.280,95%CI=0.084-0.932,P=0.038),漂浮物数>3(OR=0.343,95%CI=0.172-0.683,P=0.002),在多元二元逻辑回归分析中，具有串状模式（OR=0.370，95％CI=0.166-0.824，P=0.015）和块状模式（OR=0.299，95％CI=0.090-0.993，P=0.049）的漂浮物与VDM症状的显着自发缓解呈负相关。
结论：约40%的VDM伴PVD患者在长期随访期间可能经历显著的自发缓解。非近视性和较少漂浮物的患者更有可能感到VDM症状缓解。具有线状或块状图案的漂浮物不太可能自发缓解。
