Abstract：
BACKGROUND: Menstrual cycle length (MCL) and ovarian response varies widely among women of childbearing age. They are provided with anti-Mu¨llerian hormone (AMH) cutoffs for \"normal\" and \"weakened\" ovarian responses, which give an early warning of the onset of decreased ovarian response.
METHODS: This was a retrospective study in women aged 21 to 35 years with MCLs of 21-35 days receiving in vitro fertilization (IVF) treatment at Center for Reproductive Medicine from October 2018 to October 2021. Intergroup variables were balanced using propensity score matching based on age and BMI, and each case patient (patients with MCLs of 21-25 days) was matched with three control patients (patients with MCLs of 26-35 days). A receiver operating characteristic curve was used to calculate the AMH cutoff values.
RESULTS: We included 135 patients with MCLs of 21-25 days and 405 matched control patients with MCLs of 26-35 days who received IVF treatment. The case group had significantly fewer retrieved oocytes, lower AMH values and higher initial and total Gonadotropin (Gn) levels during controlled ovarian hyperstimulation than the control group. The ovarian response began to decrease when AMH was < 3.5 ng/ml in the case group and < 2.7 ng/ml in the control group.
CONCLUSIONS: In young women with MCLs of 21-35 days, short MCL was negatively correlated with AMH values and the number of oocytes retrieved. In patients with MCLs of 21-25 days and 26-35 days, the AMH cutoff values corresponding to the onset of decreased ovarian response were 3.5 ng/ml and 2.7 ng/ml, respectively.
METHODS: This was a retrospective study in women aged 21 to 35 years with MCLs of 21-35 days receiving in vitro fertilization (IVF) treatment at Center for Reproductive Medicine from October 2018 to October 2021. Intergroup variables were balanced using propensity score matching based on age and BMI, and each case patient (patients with MCLs of 21-25 days) was matched with three control patients (patients with MCLs of 26-35 days). A receiver operating characteristic curve was used to calculate the AMH cutoff values.
RESULTS: We included 135 patients with MCLs of 21-25 days and 405 matched control patients with MCLs of 26-35 days who received IVF treatment. The case group had significantly fewer retrieved oocytes, lower AMH values and higher initial and total Gonadotropin (Gn) levels during controlled ovarian hyperstimulation than the control group. The ovarian response began to decrease when AMH was < 3.5 ng/ml in the case group and < 2.7 ng/ml in the control group.
CONCLUSIONS: In young women with MCLs of 21-35 days, short MCL was negatively correlated with AMH values and the number of oocytes retrieved. In patients with MCLs of 21-25 days and 26-35 days, the AMH cutoff values corresponding to the onset of decreased ovarian response were 3.5 ng/ml and 2.7 ng/ml, respectively.
摘要：
背景：育龄妇女的月经周期长度（MCL）和卵巢反应差异很大。为“正常”和“减弱”卵巢反应提供抗穆勒氏激素（AMH）截止值，这可以早期警告卵巢反应减少的开始。
方法：这是一项针对21至35岁的女性的回顾性研究，这些女性患有21-35天的MCL，于2018年10月至2021年10月在生殖医学中心接受体外受精（IVF）治疗。使用基于年龄和BMI的倾向评分匹配来平衡组间变量，每个病例患者（MCLs为21-25天的患者）与三名对照患者（MCLs为26-35天的患者）相匹配。使用接收器工作特征曲线来计算AMH截止值。
结果：我们包括135例21-25天的MCL患者和405例接受IVF治疗的26-35天的MCL患者。病例组获得的卵母细胞明显较少，与对照组相比，控制性超排卵期间AMH值较低，初始和总促性腺激素（Gn）水平较高。当AMH在病例组中<3.5ng/ml和在对照组中<2.7ng/ml时,卵巢反应开始降低。
结论：在MCLs为21-35天的年轻女性中，短MCL与AMH值和卵母细胞数量呈负相关。在MCLs为21-25天和26-35天的患者中，对应于卵巢反应降低发作的AMH临界值为3.5ng/ml和2.7ng/ml,分别。
方法：这是一项针对21至35岁的女性的回顾性研究，这些女性患有21-35天的MCL，于2018年10月至2021年10月在生殖医学中心接受体外受精（IVF）治疗。使用基于年龄和BMI的倾向评分匹配来平衡组间变量，每个病例患者（MCLs为21-25天的患者）与三名对照患者（MCLs为26-35天的患者）相匹配。使用接收器工作特征曲线来计算AMH截止值。
结果：我们包括135例21-25天的MCL患者和405例接受IVF治疗的26-35天的MCL患者。病例组获得的卵母细胞明显较少，与对照组相比，控制性超排卵期间AMH值较低，初始和总促性腺激素（Gn）水平较高。当AMH在病例组中<3.5ng/ml和在对照组中<2.7ng/ml时,卵巢反应开始降低。
结论：在MCLs为21-35天的年轻女性中，短MCL与AMH值和卵母细胞数量呈负相关。在MCLs为21-25天和26-35天的患者中，对应于卵巢反应降低发作的AMH临界值为3.5ng/ml和2.7ng/ml,分别。
