PDF(Pubmed)
Abstract：
Corneal transplantation is considered a convenient strategy for various types of corneal disease needs. Even though it has been applied as a suitable solution for most corneal disorders, patients still face several issues due to a lack of healthy donor corneas, and rejection is another unknown risk of corneal transplant tissue. Corneal tissue engineering (CTE) has gained significant consideration as an efficient approach to developing tissue-engineered scaffolds for corneal healing and regeneration. Several approaches are tested to develop a substrate with equal transmittance and mechanical properties to improve the regeneration of cornea tissue. In this regard, bioprinted scaffolds have recently received sufficient attention in simulating corneal structure, owing to their spectacular spatial control which produces a three-cell-loaded-dimensional corneal structure. In this review, the anatomy and function of different layers of corneal tissue are highlighted, and then the potential of the 3D bioprinting technique for promoting corneal regeneration is also discussed.
摘要：
角膜移植被认为是满足各种类型角膜疾病需求的便捷策略。尽管它已被用作大多数角膜疾病的合适解决方案，由于缺乏健康的供体角膜，患者仍然面临一些问题，排斥反应是角膜移植组织的另一个未知风险。角膜组织工程（CTE）作为开发用于角膜愈合和再生的组织工程支架的有效方法已得到了广泛的考虑。测试了几种方法来开发具有相等透射率和机械性能的基材，以改善角膜组织的再生。在这方面,生物打印的支架最近在模拟角膜结构方面得到了足够的重视，由于它们壮观的空间控制，产生了三细胞加载的三维角膜结构。在这次审查中,强调了不同层角膜组织的解剖结构和功能，然后讨论了3D生物打印技术促进角膜再生的潜力。
