Abstract：
Pyruvic acid has numerous applications in the food, chemical, and pharmaceutical industries. The high costs of chemical synthesis have prevented the extensive use of pyruvate for many applications. Metabolic engineering and traditional strategies for mutation and selection have been applied to microorganisms to enhance their ability to produce pyruvate. In the past decades, different microbial strains were generated to enhance their pyruvate production capability. In addition to the development of genetic engineering and metabolic engineering in recent years, the metabolic transformation of wild-type yeast, E. coli, and so on to produce high-yielding pyruvate strains has become a hot spot. The strategy and the understanding of the central metabolism directly related to pyruvate production could provide valuable information for improvements in fermentation products. One of the goals of this review was to collect information regarding metabolically engineered strains and the microbial fermentation processes used to produce pyruvate in high yield and productivity.
摘要：
丙酮酸在食品中有着广泛的应用,化学,和制药行业。化学合成的高成本阻碍了丙酮酸盐在许多应用中的广泛使用。代谢工程和用于突变和选择的传统策略已应用于微生物以增强其产生丙酮酸的能力。在过去的几十年里，产生不同的微生物菌株以增强其丙酮酸的生产能力。除了近年来基因工程和代谢工程的发展外，野生型酵母的代谢转化，大肠杆菌，等生产高产丙酮酸菌株已成为热点。与丙酮酸生产直接相关的中心代谢的策略和理解可以为发酵产物的改进提供有价值的信息。这篇综述的目标之一是收集有关代谢工程菌株和用于高产率和生产率生产丙酮酸的微生物发酵过程的信息。
