关键词: amphiboles asbestos fibers chrysotile electron microscopy occupational diseases peritoneal mesothelioma scoping review

来  源:   DOI:10.3390/life12121969

Abstract:
Peritoneal tissue is the second most affected site by malignant mesothelioma linked to asbestos exposure. This scoping review aims to summarize the findings of the studies in which asbestos fibers in the peritoneum were quantified by electron microscopy, occasionally associated with spectroscopy, both in neoplastic and non-neoplastic tissue. The 9 studies selected comprised 62 cases, out of whom 100 samples were analyzed. Asbestos fibers were detected in 58 samples (58%). In addition, 28 cases had diagnosis of peritoneal mesothelioma. For 32 cases, a lung tumor sample was available: 28/32 samples analyzed presented asbestos fibers; 18/32 reported amphiboles with a range from not detected to 14.2 million fibers per gram of dry tissue (mfgdt); 18/32 reported chrysotile, with a range of 0 to 90 mfgdt. The studies were heterogeneous for type of samples, analytical technology, and circumstances of exposure to asbestos. To evaluate asbestos fibers in the peritoneum and to better understand the association between asbestos exposure and malignant peritoneal mesothelioma, it is desirable that the search for asbestos fibers becomes a routine process every time peritoneal tissue is accessible.
摘要:
腹膜组织是与石棉接触有关的恶性间皮瘤的第二大影响部位。这项范围审查旨在总结通过电子显微镜对腹膜中的石棉纤维进行定量的研究结果,偶尔与光谱学有关,在肿瘤组织和非肿瘤组织中。选择的9项研究包括62例,分析了其中100个样本。在58份样品中检测到石棉纤维(58%)。此外,28例诊断为腹膜间皮瘤。32例,可获得肺肿瘤样本:28/32个样本分析显示石棉纤维;18/32个报告的闪石,范围从未检测到到1420万纤维/克干组织(mfgdt);18/32报告的温石棉,范围为0到90mfgdt。这些研究对于样本类型是异质的,分析技术,以及接触石棉的情况。为了评估腹膜中的石棉纤维,并更好地了解石棉暴露与恶性腹膜间皮瘤之间的关系,希望每次进入腹膜组织时,寻找石棉纤维成为常规过程。
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