Abstract：
A captive-kept adult male tiger presented with a large cutaneous and subcutaneous mass on the thigh with a fistula. During sedation, multiple nodules were detected and samples for a histopathological exam were collected. Histologically, granulomatous panniculitis and dermatitis were seen around dense aggregates of pigmented fungal hyphae, and a diagnosis of phaeohyphomycosis was made; considering the clinical features, it was classified as a eumycotic mycetoma. This is a rarely reported subcutaneous fungal infection in humans and animals, caused by dematiaceous fungi. Clinically, it is characterized by tumefaction, fistulous sinus tracts, and the formation of macroscopically visible grains. In the literature, only a few infections in wild felids have been reported. In this case, Fontana-Masson staining better showed pigmentation and panfungal PCR and sequencing identified Madurella pseudomyectomatis (OP623507) as the causative agent. Systemic therapy with oral administration of itraconazole was planned, but the patient died during the first period of treatment. The animal was not submitted for post-mortem examination. Visceral dissemination of the agent cannot be excluded. To the authors\' knowledge, this is the first report of eumycotic mycetoma by Madurella pseudomycetomatis in a captive tiger.
摘要：
圈养的成年雄性老虎在大腿上有一个大的皮肤和皮下肿块，并有瘘管。在镇静期间,检测到多个结节,并收集组织病理学检查样本.组织学上,肉芽肿性脂膜炎和皮炎见于色素性真菌菌丝致密聚集体周围,并诊断为带真菌病；考虑到临床特征，它被归类为真人真菌瘤。这是一种很少报道的人和动物皮下真菌感染，由脱毛真菌引起。临床上,它的特点是锻炼，瘘管窦道,和宏观可见晶粒的形成。在文学中,据报道，野生猫科动物只有少数感染。在这种情况下,Fontana-Masson染色更好地显示了色素沉着和泛真菌PCR，测序鉴定了假单胞菌Madurella（OP623507）为病原体。计划口服伊曲康唑的全身治疗，但患者在治疗的第一阶段死亡。该动物未提交验尸。不能排除药物的内脏传播。就作者所知，这是马杜雷拉假孢子虫在圈养老虎中首次报告的真金病菌瘤。
