Abstract：
Radiation therapy represents, together with surgery and systemic treatment, the triad on which the current management of patients with breast cancer is based, achieving high control and survival rates. In recent years we have witnessed a (r)evolution in the conception of breast cancer treatment. The classic scheme of surgery followed by systemic treatment and radiotherapy is being subverted and it is becoming more and more frequent to propose the primary administration of systemic treatment before surgery, seeking to maximize its effect and favoring not only the performance of more conservative surgeries but also, in selected cases, increasing the rates of disease-free survival and overall survival. Radiotherapy is also evolving toward a change in perspective: considering preoperative primary administration of radiotherapy may be useful in selected groups. Advances in radiobiological knowledge, together with technological improvements that are constantly being incorporated into clinical practice, support the administration of increasingly reliable, precise, and effective radiotherapy, as well as its safe combination with antitumor drugs or immunotherapy in the primary preoperative context. In this paper, we present a narrative review of the usefulness of preoperative radiotherapy for breast cancer patients and the possibilities for its combination with other therapies.
摘要：
目的：放射治疗代表，加上手术和全身治疗，目前乳腺癌患者管理的基础是三合会，实现高控制率和存活率。近年来，我们目睹了乳腺癌治疗概念的发展。手术后进行全身治疗和放疗的经典方案正在被颠覆，提出在手术前进行全身治疗的方案越来越频繁，寻求最大限度地发挥其作用，不仅有利于保守手术的性能，在选定的情况下，提高无病生存率和总生存率。放射疗法也正在朝着改变的方向发展：考虑到术前初次给予放射疗法可能对某些组有用。放射生物学知识的进展，加上不断纳入临床实践的技术改进，支持越来越可靠的管理，精确，和有效的放射治疗，以及在主要术前背景下与抗肿瘤药物或免疫疗法的安全组合。在本文中,我们对乳腺癌患者术前放疗的有效性及其与其他疗法联合应用的可能性进行了叙述性综述.
