Abstract：
OBJECTIVE: The purpose of this study was to analyze the features of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in hepatic epithelioid hemangioendothelioma (HEHE).
METHODS: We retrospectively analyzed the US images (grayscale, color Doppler and CEUS) of the patients with histopathologically confirmed HEHE in our hospital from March 2015 to August 2021 who had underwent a US investigation.
RESULTS: A total of 13 patients were reported during the study period (seven men, aged from 23 to 62 years, with an average age of 40 years). The unifocal, multifocal, and diffuse lesions were 2, 9, and 2, respectively. Five patients (5/13) had liver involvement of both lobes, and eight (8/13) patients had only right lobe involvement. The maximum diameter of the lesions ranged from 1.9 to 7.0 cm. The grayscale US of HEHE mainly showed multiple hypoechoic lesions (n=9) near the capsule of the right lobe of the liver, with well-defined margins (n=7), accompanied by a hypoechoic halo (n=3) or capsule retraction (n=4) and calcification (n=8). Color Doppler US can detect blood flow in the lesion (n=8). CEUS was performed in five patients (5/13). The enhancement pattern of CEUS varied in the arterial phase, mainly including rim-like hyper-enhancement (n=2) and inhomogeneous hypo-enhancement (n=2), but was approximately the same in the portal venous phase and the late venous phase, both showing varying degrees of regression.
CONCLUSIONS: The grayscale US and CEUS seem to provide some reference value for diagnosing HEHE.
METHODS: We retrospectively analyzed the US images (grayscale, color Doppler and CEUS) of the patients with histopathologically confirmed HEHE in our hospital from March 2015 to August 2021 who had underwent a US investigation.
RESULTS: A total of 13 patients were reported during the study period (seven men, aged from 23 to 62 years, with an average age of 40 years). The unifocal, multifocal, and diffuse lesions were 2, 9, and 2, respectively. Five patients (5/13) had liver involvement of both lobes, and eight (8/13) patients had only right lobe involvement. The maximum diameter of the lesions ranged from 1.9 to 7.0 cm. The grayscale US of HEHE mainly showed multiple hypoechoic lesions (n=9) near the capsule of the right lobe of the liver, with well-defined margins (n=7), accompanied by a hypoechoic halo (n=3) or capsule retraction (n=4) and calcification (n=8). Color Doppler US can detect blood flow in the lesion (n=8). CEUS was performed in five patients (5/13). The enhancement pattern of CEUS varied in the arterial phase, mainly including rim-like hyper-enhancement (n=2) and inhomogeneous hypo-enhancement (n=2), but was approximately the same in the portal venous phase and the late venous phase, both showing varying degrees of regression.
CONCLUSIONS: The grayscale US and CEUS seem to provide some reference value for diagnosing HEHE.
摘要：
目的：本研究的目的是分析肝上皮样血管内皮瘤（HEHE）的常规超声（US）和超声造影（CEUS）的特征。
方法：我们回顾性分析了美国图像(灰度，2015年3月至2021年8月在我院接受美国调查的经组织病理学证实为HEHE的患者的彩色多普勒和CEUS）。
结果：在研究期间共报告了13例患者（7例男性，年龄从23岁到62岁，平均年龄为40岁)。Theunifocal,多焦点,和弥漫性病变分别为2、9和2。5例患者（5/13）两叶肝脏受累，8例（8/13）患者仅右叶受累。病灶最大直径1.9～7.0cm。HEHE的灰度US主要显示肝脏右叶囊附近的多个低回声病变（n=9），具有明确定义的边距(n=7)，伴有低回声晕（n=3）或胶囊收缩（n=4）和钙化（n=8）。彩色多普勒超声可以检测病变中的血流（n=8）。5例患者行CEUS（5/13）。CEUS的增强模式在动脉阶段有所不同，主要包括边缘样过度增强(n=2)和非均匀低增强(n=2)，但是在门静脉阶段和静脉晚期阶段大致相同，两者都表现出不同程度的回归。
结论：灰度US和CEUS似乎为HEHE的诊断提供了一定的参考价值。
方法：我们回顾性分析了美国图像(灰度，2015年3月至2021年8月在我院接受美国调查的经组织病理学证实为HEHE的患者的彩色多普勒和CEUS）。
结果：在研究期间共报告了13例患者（7例男性，年龄从23岁到62岁，平均年龄为40岁)。Theunifocal,多焦点,和弥漫性病变分别为2、9和2。5例患者（5/13）两叶肝脏受累，8例（8/13）患者仅右叶受累。病灶最大直径1.9～7.0cm。HEHE的灰度US主要显示肝脏右叶囊附近的多个低回声病变（n=9），具有明确定义的边距(n=7)，伴有低回声晕（n=3）或胶囊收缩（n=4）和钙化（n=8）。彩色多普勒超声可以检测病变中的血流（n=8）。5例患者行CEUS（5/13）。CEUS的增强模式在动脉阶段有所不同，主要包括边缘样过度增强(n=2)和非均匀低增强(n=2)，但是在门静脉阶段和静脉晚期阶段大致相同，两者都表现出不同程度的回归。
结论：灰度US和CEUS似乎为HEHE的诊断提供了一定的参考价值。
