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Abstract：
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located at the DLK1-MEG3 site of human chromosome 14q32.3. The expression of MEG3 in various tumors is substantially lower than that in normal adjacent tissues, and deletion of MEG3 expression is involved in the occurrence of many tumors. The high expression of MEG3 could inhibit the occurrence and development of tumors through several mechanisms, which has become a research hotspot in recent years. As a member of tumor suppressor lncRNAs, MEG3 is expected to be a new target for tumor diagnosis and treatment. This review discusses the molecular mechanisms of MEG3 in different tumors and future challenges for the diagnosis and treatment of cancers through MEG3.
摘要：
长非编码RNA（lncRNA）母体表达基因3（MEG3）是位于人类染色体14q32.3的DLK1-MEG3位点的lncRNA。MEG3在各种肿瘤中的表达明显低于正常癌旁组织，MEG3表达的缺失与许多肿瘤的发生有关。MEG3的高表达可能通过多种机制抑制肿瘤的发生发展,成为近年来的研究热点。作为肿瘤抑制lncRNAs的一员，MEG3有望成为肿瘤诊断和治疗的新靶点。本文综述了MEG3在不同肿瘤中的分子机制以及通过MEG3诊断和治疗癌症的未来挑战。
