关键词: PDE-6 Retinal photoreceptor cells Sildenafil citrate

来  源:   DOI:10.1016/j.ajoc.2022.101761   PDF(Pubmed)

Abstract:
UNASSIGNED: To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate.
UNASSIGNED: A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil citrate at a dose of 200 mg daily for two years. mERG and OCT examination revealed persistent damage of retinal photoreceptor cells. The symptoms did not disappear after 3 months off the medication.
UNASSIGNED: Long term excessive use of overdose sildenafil citrate can cause serious damage to retinal photoreceptor cells. The retinal side effects of sildenafil citrate still need to be further investigated, and the administration of systemic overdose also needs to be considered by all physicians, not just ophthalmologists.
摘要:
未经证实:报告一例长期服用枸橼酸西地那非过量患者的眼部结构改变。
UNASSIGNED:一名28岁男性出现在我们的门诊诊所,在服用西地那非,每天200毫克,持续两年后,双眼出现耀斑感。mERG和OCT检查显示视网膜感光细胞持续受损。停药3个月后症状没有消失。
UNASSIGNED:长期过量使用过量的枸橼酸西地那非会对视网膜感光细胞造成严重损害。枸橼酸西地那非的视网膜副作用仍需进一步研究,全身用药过量也需要所有医生考虑,不仅仅是眼科医生.
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