PDF(Pubmed)
Abstract：
UNASSIGNED: Cancer is an important disease and can occur anywhere in the body. It is caused by uncontrolled cell growth that spreads to other body parts. This study extensively investigated the transmembrane receptor tissue factor (TF), which is the key motivator of the clotting cascade and plays an essential role in cancer-associated coagulation. TF is considered to be aberrantly expressed in various tumors and appears to promote tumor angiogenesis and metastasis. Therefore, this study was performed to explain the pathological characteristics of TF expression and to discuss future cancer therapies that target TF.
UNASSIGNED: We extensively reviewed the literature on TF published in PubMed, and discussed the effect of TF on tumor progression and TF-targeted therapeutics.
UNASSIGNED: This review aimed to uncover how TFs contribute to tumor progression and cancer-associated thrombosis and summarize TF-based targeted therapy. Multiple functions and mechanisms of the TF in cancer-associated thrombosis and tumor progression were discussed.
UNASSIGNED: The current literature has confirmed that the TF is involved in the hypercoagulable state of tumors and promotes malignant tumors through coagulation-dependent or non-coagulation-dependent pathways. TF-dependent signaling is also involved in divergent cancer progression. Thus, TF-targeted therapeutics could have broad clinical applicability for the treatment of tumors.
UNASSIGNED: We extensively reviewed the literature on TF published in PubMed, and discussed the effect of TF on tumor progression and TF-targeted therapeutics.
UNASSIGNED: This review aimed to uncover how TFs contribute to tumor progression and cancer-associated thrombosis and summarize TF-based targeted therapy. Multiple functions and mechanisms of the TF in cancer-associated thrombosis and tumor progression were discussed.
UNASSIGNED: The current literature has confirmed that the TF is involved in the hypercoagulable state of tumors and promotes malignant tumors through coagulation-dependent or non-coagulation-dependent pathways. TF-dependent signaling is also involved in divergent cancer progression. Thus, TF-targeted therapeutics could have broad clinical applicability for the treatment of tumors.
摘要：
UNASSIGNED：癌症是一种重要的疾病，可以发生在身体的任何地方。它是由传播到其他身体部位的不受控制的细胞生长引起的。这项研究广泛调查了跨膜受体组织因子（TF），这是凝血级联的关键动机，在癌症相关的凝血中起着至关重要的作用。TF被认为在各种肿瘤中异常表达,并且似乎促进肿瘤血管生成和转移。因此,进行这项研究是为了解释TF表达的病理学特征，并讨论针对TF的未来癌症治疗。
UNASSIGNED：我们广泛回顾了发表在PubMed上的关于TF的文献，并讨论了TF对肿瘤进展的影响和TF靶向治疗。
UNASSIGNED：本综述旨在揭示TF如何促进肿瘤进展和癌症相关血栓形成，并总结基于TF的靶向治疗。讨论了TF在癌症相关血栓形成和肿瘤进展中的多种功能和机制。
UNASSIGNED：当前文献已证实，TF参与肿瘤的高凝状态，并通过凝血依赖性或非凝血依赖性途径促进恶性肿瘤。TF依赖性信号传导也涉及不同的癌症进展。因此，TF靶向治疗剂可具有用于治疗肿瘤的广泛临床适用性。
UNASSIGNED：我们广泛回顾了发表在PubMed上的关于TF的文献，并讨论了TF对肿瘤进展的影响和TF靶向治疗。
UNASSIGNED：本综述旨在揭示TF如何促进肿瘤进展和癌症相关血栓形成，并总结基于TF的靶向治疗。讨论了TF在癌症相关血栓形成和肿瘤进展中的多种功能和机制。
UNASSIGNED：当前文献已证实，TF参与肿瘤的高凝状态，并通过凝血依赖性或非凝血依赖性途径促进恶性肿瘤。TF依赖性信号传导也涉及不同的癌症进展。因此，TF靶向治疗剂可具有用于治疗肿瘤的广泛临床适用性。
