Subjects with sCSF leaks and controls were prospectively recruited. ONSD, sex, and body mass index (BMI) were analyzed. For sCSF leak subjects, ultrasonography was performed at the time of LD opening and each pressure check postoperatively, including the acetazolamide response. In control patients, measurements were obtained at the time of surgery. Pearson\'s correlation between ONSD and ICP was performed.
Subjects with sCSF leaks (n = 9, age 52.4 ± 9.5, all female) and controls (n = 8, age 60.1 ± 14.8, two females) had significantly different BMIs, 38.4 ± 8.1 vs. 29.2 ± 4.8, t(15) = 2.793, p = 0.014. ONSD was strongly correlated with ICP measurements (r = 0.583, p = 0.002). However, percentage change in ONSD and ICP measurements were more strongly correlated (r = 0.733, p < 0.001). Patients with sCSF leaks had significantly higher ONSDs than controls, 0.63 cm ± 0.044 vs. 0.56 cm ± 0.074, t(15) = 2.329, p = 0.034.
ONSD significantly correlated with ICP in sCSF leak patients and was wider in sCSF leak subjects than controls. Ultrasonography has utility in monitoring the ICP response to acetazolamide.
方法:前瞻性招募患有sCSF泄漏和对照的受试者。ONSD,性别,分析体重指数(BMI)。对于sCSF泄漏受试者,超声检查在LD打开压力时进行,每次检查术后,包括乙酰唑胺反应。在控制患者中,测量是在手术时获得的。进行了ONSD和ICP之间的Pearson相关性。
结果:患有sCSF泄漏的受试者(n=9,年龄52.4±9.5,均为女性)和对照组(n=8,年龄60.1±14.8,2名女性)的BMI显着不同(38.4±8.1,vs.29.2±4.8,t(15)=2.793,p=0.014)。ONSD与LP测量值密切相关(r=0.583,p=0.002)。然而,ONSD和LP测量值的变化百分比相关性更强(r=0.733,p<0.001).sCSF泄漏患者的ONSD明显高于对照组(0.63cm±0.044,vs.0.56cm±0.074,t(15=2.329,p=0.034)。
结论:在sCSF渗漏患者中,ONSD与ICP显著相关,在sCSF渗漏患者中,ONSD比对照组更广泛。超声检查可用于监测ICP对乙酰唑胺的反应。本文受版权保护。保留所有权利。