RESULTS: 170 patients were included. The median duration of stay in ICU and hospital was 8 (3-17) and 37 (14-71) days, respectively. The median time from admission to first surgical debridement was 1 (0-2) day but 69.9% of patients were re-operated with a median of 1 (0-3) additional debridement. Inter-hospital transfer was necessary in 52.4% of patients. 80.2% of patients developed organ failures during the course of ICU stay with 51.8% of patients requiring invasive mechanical ventilation, 77.2% needing vasopressor support and 27.7% renal replacement therapy. In-ICU and in-hospital mortality rates were 21.8% and 28.8%, respectively. There was no significant difference between patients with abdomino-perineal NSTIs (n = 33) and others (n = 137) in terms of in-hospital or ICU mortality. Yet, immunocompromised patients (n = 43) showed significantly higher ICU and in-hospital mortality rates than non-immunocompromised patients (n = 127) (37.2% vs. 16.5%, p = 0.009, and 53.5% vs. 20.5%, p < 0.001). Factors associated with a complicated course were the presence of a polymicrobial infection (adjusted odds ratio [aOR = 3.18 (1.37-7.35); p = 0.007], of a bacteremia [aOR = 3.29 (1.14-9.52); p = 0.028] and a higher SAPS II score [aOR = 1.05 (1.02-1.07); p < 0.0001]. 62.3% of patients were re-hospitalized within 6 months.
CONCLUSIONS: In this retrospective multicenter study, we showed that patients with NSTI required complex management and are major consumers of care. Two-thirds of them underwent a complicated hospital course, associated with a higher SAPS II score, a polymicrobial NSTI and a bacteremia.
结果:纳入170例患者。在ICU和医院的平均住院时间为8(3-17)和37(14-71)天,分别。从入院到首次手术清创的中位时间为1(0-2)天,但69.9%的患者再次手术,中位时间为1(0-3)次额外清创。52.4%的患者需要进行医院间转移。80.2%的患者在ICU期间出现器官衰竭,51.8%的患者需要有创机械通气,77.2%需要血管加压药支持和27.7%的肾脏替代治疗。ICU和院内死亡率分别为21.8%和28.8%,分别。在住院或ICU死亡率方面,腹部-会阴NSTIs患者(n=33)和其他患者(n=137)之间没有显着差异。然而,免疫功能低下患者(n=43)的ICU和院内死亡率明显高于非免疫功能低下患者(n=127)(37.2%vs.16.5%,p=0.009,53.5%与20.5%,p<0.001)。与复杂病程相关的因素是多重微生物感染的存在(调整后的比值比[aOR=3.18(1.37-7.35);p=0.007],菌血症[aOR=3.29(1.14-9.52);p=0.028]和更高的SAPSII评分[aOR=1.05(1.02-1.07);p<0.0001]。62.3%的患者在6个月内再次住院。
结论:在这项回顾性多中心研究中,我们发现NSTI患者需要复杂的管理,并且是主要的医疗消费者.其中三分之二的人接受了复杂的医院治疗,与更高的SAPSII评分相关,多微生物NSTI和菌血症。