Abstract：
COVID-19 vaccine is critical in preventing SARS-CoV-2 infection and transmission. However, obesity\'s effect on immune responses to COVID-19 vaccines is still unknown. We performed a meta-analysis of the literature and compared antibody responses with COVID-19 vaccines among persons with and without obesity. We used Pubmed, Embase, Web of Science, and Cochrane Library to identify all related studies up to April 2022. The Stata.14 software was used to analyze the selected data. Eleven studies were included in the present meta-analysis. Five of them provided absolute values of antibody titers in the obese group and non-obese group. Overall, we found that the obese population was significantly associated with lower antibody titers (standardized mean difference [SMD] = -0.228, 95% CI [-0.437, -0.019], P < 0.001) after COVID-19 vaccination. Significant heterogeneity was present in most pooled analyses but was reduced after subgroup analyses. No publication bias was observed in the present analysis. The Trim and Fill method did not change the results in the primary analysis. The present meta-analysis suggested that obesity was significantly associated with decreased antibody responses to SARS-CoV-2 vaccines. Future studies should be performed to unravel the mechanism of response to the COVID-19 vaccine in obese individuals.
摘要：
COVID-19疫苗对预防SARS-CoV-2感染和传播至关重要。然而,肥胖对COVID-19疫苗免疫反应的影响仍然未知。我们对文献进行了荟萃分析，并比较了有肥胖和没有肥胖的人与COVID-19疫苗的抗体反应。我们用Pubmed,Embase,WebofScience,和Cochrane图书馆确定截至2022年4月的所有相关研究。使用Stata.14软件对所选数据进行分析。本荟萃分析包括11项研究。其中五个提供了肥胖组和非肥胖组的抗体滴度的绝对值。总的来说,我们发现肥胖人群与较低的抗体滴度显著相关(标准化平均差[SMD]=-0.228,95%CI[-0.437,-0.019],P<0.001）在COVID-19疫苗接种后。在大多数汇总分析中存在显著的异质性，但在亚组分析后降低。在本分析中未观察到发表偏倚。修剪和填充方法没有改变主要分析中的结果。目前的荟萃分析表明，肥胖与SARS-CoV-2疫苗的抗体反应降低显着相关。未来的研究应该进行，以揭示肥胖个体对COVID-19疫苗的反应机制。
