UNASSIGNED: Cross-sectional study.
UNASSIGNED: Patients were divided into the control and glaucoma groups. The control group was patients with senile cataracts. The glaucoma group consisted of patients diagnosed for the first time as primary open-angle glaucoma (POAG) or primary angle closure glaucoma (PACG). Exclusion criteria were secondary glaucoma and patients with systemic disease. A complete cataract examination was done for all patients, and glaucoma examinations for the glaucoma group. In both groups, the IMA aqueous humor was obtained during cataract and glaucoma procedure. Serum levels of IMA, malondialdehyde (MDA), and tumor necrosis factor alpha (TNF-α) were examined during preoperative examinations.
UNASSIGNED: Control group comprised 33 participants, and glaucoma group 41 patients (21 PACG and 20 POAG). Mean IMA aqueous humor (AQH) levels found in cataract group 6.039±3.16 ng/mL, glaucoma group 14.89±6.08 ng/mL, PACG group 12.69±6.25 ng/mL and POAG group 17.33±4.988 mg/mL. Mean IMA serum levels in cataract group 14.75±6.53 ng/mL, glaucoma group 13.89±6.53 ng/mL, PACG group 12.79±6.46 ng/mL± and POAG group 14.93±10.74 ng/mL. Glaucoma group had significant higher level of IMA in aqueous humor compared to control group, but opposite findings in serum IMA levels between groups. POAG patients had a higher aqueous IMA level compared to PACG group and correlated significantly with IOP. IMA AQH also negatively correlated to the RNFL thickness in both POAG and PACG group. Cut off 9.5 ng/mL was considered as a normal limit value to differentiate between control and glaucoma group.
UNASSIGNED: Primary glaucoma patients showed a significantly increased level of IMA AQH as a local ischemic biomarker compared to the control group. Systemic oxidative activity is not a representation of local ocular oxidative stress in both cataract and glaucoma group.
未经评估:横断面研究。
UNASSIGNED:患者分为对照组和青光眼组。对照组为老年性白内障患者。青光眼组由首次诊断为原发性开角型青光眼(POAG)或原发性闭角型青光眼(PACG)的患者组成。排除标准为继发性青光眼和全身性疾病患者。对所有患者进行了完整的白内障检查,和青光眼组的青光眼检查。在这两组中,在白内障和青光眼手术期间获得IMA房水。血清IMA水平,丙二醛(MDA),术前检查肿瘤坏死因子α(TNF-α)。
未经评估:对照组由33名参与者组成,青光眼组41例(21PACG和20POAG)。在白内障组中发现的平均IMA房水(AQH)水平6.039±3.16ng/mL,青光眼组14.89±6.08ng/mL,PACG组12.69±6.25ng/mL,POAG组17.33±4.988mg/mL。白内障组平均IMA血清水平14.75±6.53ng/mL,青光眼组13.89±6.53ng/mL,PACG组12.79±6.46ng/mL±POAG组14.93±10.74ng/mL。青光眼组房水IMA水平明显高于对照组,但组间血清IMA水平相反。与PACG组相比,POAG患者的房水IMA水平较高,并且与IOP显着相关。在POAG和PACG组中,IMAAQH也与RNFL厚度呈负相关。切除9.5ng/mL被认为是区分对照组和青光眼组的正常极限值。
UNASSIGNED:与对照组相比,原发性青光眼患者作为局部缺血生物标志物的IMAAQH水平显著升高。在白内障和青光眼组中,系统性氧化活性均不代表局部眼部氧化应激。