UNASSIGNED: Evaluation of a diagnostic test or technology.
UNASSIGNED: Healthy subjects with no history of refractive surgery, divided into 2 cohorts on the basis of their axial length (AL).
UNASSIGNED: We present a noninvasive technique to quantitatively assess the pulsatile deformation of the ONH tissue by combining high-frequency OCT imaging and widely available image processing algorithms. We performed a thorough validation of the approach, numerically and experimentally, evaluating the sensitivity of the method to artificially induced deformation and its robustness to different noise levels. We performed deformation measurements in cohorts of healthy (n = 9) and myopic (n = 5) subjects in different physiological strain conditions by calculating the amplitude of tissue displacement in both the primary position and abduction. The head rotation was measured using a goniometer. During imaging in abduction, the head was rotated 40° ± 3°, and subjects were instructed to direct their gaze toward the OCT visual target.
UNASSIGNED: Pulsatile tissue displacement maps.
UNASSIGNED: The robustness of the method was assessed using artificial deformations and increasing noise levels. The results show acceptable absolute errors before the noise simulations grossly exaggerate image degradation. For the group of subjects with AL of < 25 mm (n = 9), the median pulsatile displacement of the ONH was 7.8 ± 1.3 μm in the primary position and 8.9 ± 1.2 μm in abduction. The Wilcoxon test showed a significant difference (P ≤ 0.005) between the 2 paired measures. Reproducibility was tested in 2 different sessions in 5 different subjects with the same intraocular pressure, and an intraclass correlation coefficient of 0.99 was obtained (P < 0.005).
UNASSIGNED: The computational pipeline demonstrated good reproducibility and had the capacity to accurately map the pulsatile deformation of the optic nerve. In a clinical setting, we detected physiological changes in normal subjects supporting its translation potential as a novel biomarker for the diagnosis and progression of optic nerve diseases.
UNASSIGNED:诊断测试或技术的评估。
未经授权:没有屈光手术史的健康受试者,根据其轴向长度(AL)分为2组。
UNASSIGNED:我们提出了一种无创技术,通过结合高频OCT成像和广泛可用的图像处理算法来定量评估ONH组织的脉动变形。我们对该方法进行了彻底的验证,数值和实验,评估该方法对人为诱发变形的敏感性及其对不同噪声水平的鲁棒性。我们通过计算主要位置和外展的组织位移幅度,在不同生理应变条件下对健康(n=9)和近视(n=5)受试者进行了变形测量。使用测角仪测量头部旋转。在外展成像期间,头部旋转40°±3°,并指示受试者将视线指向OCT视觉目标。
未经授权:搏动组织位移图。
UNASSIGNED:使用人工变形和增加的噪声水平评估了该方法的鲁棒性。在噪声模拟严重夸大图像退化之前,结果表明可以接受的绝对误差。对于AL<25mm的受试者组(n=9),ONH的中位搏动位移在主要位置为7.8±1.3μm,在外展为8.9±1.2μm。Wilcoxon检验显示两个配对测量之间存在显着差异(P≤0.005)。在具有相同眼压的5名不同受试者的2个不同会话中测试了可重复性,组内相关系数为0.99(P<0.005)。
UNASSIGNED:计算管道显示出良好的可重复性,并且具有准确绘制视神经脉动变形的能力。在临床环境中,我们检测到正常受试者的生理变化,支持其作为诊断和进展视神经疾病的新型生物标志物的翻译潜力。