PDF(Pubmed)
Abstract：
UNASSIGNED: To assess the differences in rod-mediated dark adaptation (RMDA) between different grades of age-related macular degeneration (AMD) severity using an OCT-based criterion compared with those of AMD severity using the Beckman color fundus photography (CFP)-based classification and to assess the association between the presence of subretinal drusenoid deposits (SDDs) and RMDA at different grades of AMD severity using an OCT-based classification.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: Participants from the Northern Ireland Sensory Ageing study (Queen\'s University Belfast).
UNASSIGNED: Complete RMDA (rod-intercept time [RIT]) data, CFP, and spectral-domain OCT images were extracted. Participants were stratified into 4 Beckman groups (omitting late-stage AMD) and 3 OCT-based groups. The presence and stage of SDDs were identified using OCT.
UNASSIGNED: Rod-intercept time data (age-corrected).
UNASSIGNED: Data from 459 participants (median [interquartile range] age, 65 [59-71] years) were stratified by both the classifications. Subretinal drusenoid deposits were detected in 109 eyes. The median (interquartile range) RMDA for the Beckman classification (Beckman 0-3, with 3 being intermediate age-related macular degeneration [iAMD]) groups was 6.0 (4.5-8.7), 6.6 (4.7-10.5), 5.7 (4.4-7.4), and 13.2 (6-21.1) minutes, respectively. OCT classifications OCT0-OCT2 yielded different median (interquartile range) values: 5.8 (4.5-8.5), 8.4 (5.2-13.3), and 11.1 (5.3-20.1) minutes, respectively. After correcting for age, eyes in Beckman 3 (iAMD) had statistically significantly worse RMDA than eyes in the other Beckman groups (P ≤ 0.005 for all), with no statistically significant differences between the other Beckman groups. Similarly, after age correction, eyes in OCT2 had worse RMDA than eyes in OCT0 (P ≤ 0.001) and OCT1 (P < 0.01); however, there was no statistically significant difference between eyes in OCT0 and eyes in OCT1 (P = 0.195). The presence of SDDs was associated with worse RMDA in OCT2 (P < 0.01) but not in OCT1 (P = 0.285).
UNASSIGNED: Eyes with a structural definition of iAMD have delayed RMDA, regardless of whether a CFP- or OCT-based criterion is used. In this study, after correcting for age, the RMDA did not differ between groups of eyes defined to have early AMD or normal aging, regardless of the classification. The presence of SDDs has some effect on RMDA at different grades of AMD severity.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: Participants from the Northern Ireland Sensory Ageing study (Queen\'s University Belfast).
UNASSIGNED: Complete RMDA (rod-intercept time [RIT]) data, CFP, and spectral-domain OCT images were extracted. Participants were stratified into 4 Beckman groups (omitting late-stage AMD) and 3 OCT-based groups. The presence and stage of SDDs were identified using OCT.
UNASSIGNED: Rod-intercept time data (age-corrected).
UNASSIGNED: Data from 459 participants (median [interquartile range] age, 65 [59-71] years) were stratified by both the classifications. Subretinal drusenoid deposits were detected in 109 eyes. The median (interquartile range) RMDA for the Beckman classification (Beckman 0-3, with 3 being intermediate age-related macular degeneration [iAMD]) groups was 6.0 (4.5-8.7), 6.6 (4.7-10.5), 5.7 (4.4-7.4), and 13.2 (6-21.1) minutes, respectively. OCT classifications OCT0-OCT2 yielded different median (interquartile range) values: 5.8 (4.5-8.5), 8.4 (5.2-13.3), and 11.1 (5.3-20.1) minutes, respectively. After correcting for age, eyes in Beckman 3 (iAMD) had statistically significantly worse RMDA than eyes in the other Beckman groups (P ≤ 0.005 for all), with no statistically significant differences between the other Beckman groups. Similarly, after age correction, eyes in OCT2 had worse RMDA than eyes in OCT0 (P ≤ 0.001) and OCT1 (P < 0.01); however, there was no statistically significant difference between eyes in OCT0 and eyes in OCT1 (P = 0.195). The presence of SDDs was associated with worse RMDA in OCT2 (P < 0.01) but not in OCT1 (P = 0.285).
UNASSIGNED: Eyes with a structural definition of iAMD have delayed RMDA, regardless of whether a CFP- or OCT-based criterion is used. In this study, after correcting for age, the RMDA did not differ between groups of eyes defined to have early AMD or normal aging, regardless of the classification. The presence of SDDs has some effect on RMDA at different grades of AMD severity.
摘要：
UNASSIGNED：使用基于OCT的标准评估不同等级的年龄相关性黄斑变性（AMD）严重程度与使用Beckman彩色眼底照相（CFP）分类的AMD严重程度之间的杆介导暗适应（RMDA）的差异，并使用基于OCT的AMD严重程度的不同等级评估视网膜下神经膜样沉积（SDDs）的存在与RMDA之间的关联。
未经评估：横断面研究。
UNASSIGNED：来自北爱尔兰感官衰老研究（贝尔法斯特女王大学）的参与者。
UNASSIGNED：完整的RMDA（杆截取时间[RIT]）数据，CFP,并提取谱域OCT图像。参与者被分为4个Beckman组（省略晚期AMD）和3个基于OCT的组。使用OCT鉴定SDD的存在和阶段。
UNASSIGNED：杆截取时间数据（年龄校正）。
UNASSIGNED：来自459名参与者的数据（中位[四分位数范围]年龄，65[59-71]年）按两种分类进行分层。在109只眼中检测到了视网膜下的关节软骨沉积。Beckman分类（Beckman0-3，其中3为中度年龄相关性黄斑变性[iAMD]）组的中位数（四分位数范围）RMDA为6.0（4.5-8.7），6.6(4.7-10.5),5.7(4.4-7.4),和13.2（6-21.1）分钟，分别。OCT分类OCT0-OCT2产生不同的中位数（四分位数范围）值：5.8（4.5-8.5），8.4(5.2-13.3),和11.1（5.3-20.1）分钟，分别。校正年龄后,Beckman3（iAMD）的眼睛的RMDA在统计学上显着低于其他Beckman组的眼睛（全部P≤0.005），其他Beckman组之间无统计学差异。同样，年龄校正后，OCT2眼的RMDA水平低于OCT0(P≤0.001)和OCT1(P<0.01);OCT0眼与OCT1眼比较差异无统计学意义(P=0.195)。SDDs的存在与OCT2（P<0.01）的RMDA恶化有关，而与OCT1无关（P=0.285）。
UNASSIGNED：具有iAMD结构定义的眼睛延迟了RMDA，无论是否使用基于CFP或OCT的标准。在这项研究中,校正年龄后，定义为早期AMD或正常老化的眼睛组之间的RMDA没有差异，不管是什么分类。SDDs的存在对不同程度AMD的RMDA有一定的影响。
未经评估：横断面研究。
UNASSIGNED：来自北爱尔兰感官衰老研究（贝尔法斯特女王大学）的参与者。
UNASSIGNED：完整的RMDA（杆截取时间[RIT]）数据，CFP,并提取谱域OCT图像。参与者被分为4个Beckman组（省略晚期AMD）和3个基于OCT的组。使用OCT鉴定SDD的存在和阶段。
UNASSIGNED：杆截取时间数据（年龄校正）。
UNASSIGNED：来自459名参与者的数据（中位[四分位数范围]年龄，65[59-71]年）按两种分类进行分层。在109只眼中检测到了视网膜下的关节软骨沉积。Beckman分类（Beckman0-3，其中3为中度年龄相关性黄斑变性[iAMD]）组的中位数（四分位数范围）RMDA为6.0（4.5-8.7），6.6(4.7-10.5),5.7(4.4-7.4),和13.2（6-21.1）分钟，分别。OCT分类OCT0-OCT2产生不同的中位数（四分位数范围）值：5.8（4.5-8.5），8.4(5.2-13.3),和11.1（5.3-20.1）分钟，分别。校正年龄后,Beckman3（iAMD）的眼睛的RMDA在统计学上显着低于其他Beckman组的眼睛（全部P≤0.005），其他Beckman组之间无统计学差异。同样，年龄校正后，OCT2眼的RMDA水平低于OCT0(P≤0.001)和OCT1(P<0.01);OCT0眼与OCT1眼比较差异无统计学意义(P=0.195)。SDDs的存在与OCT2（P<0.01）的RMDA恶化有关，而与OCT1无关（P=0.285）。
UNASSIGNED：具有iAMD结构定义的眼睛延迟了RMDA，无论是否使用基于CFP或OCT的标准。在这项研究中,校正年龄后，定义为早期AMD或正常老化的眼睛组之间的RMDA没有差异，不管是什么分类。SDDs的存在对不同程度AMD的RMDA有一定的影响。
