PDF(Pubmed)
Abstract：
Since the Human Genome Project was successfully completed, humanity has entered a post-genome era, and the second-generation sequencing technology has gradually progressed and become more accurate. Meanwhile, circRNAs plays a crucial role in the regulation of diseases and potential clinical applications has gradually attracted the attention of physicians. However, the mechanisms of circRNAs regulation at the cellular and molecular level of diabetic foot ulcer (DFU) is still not well-understood. With the deepening of research, there have been many recent studies conducted to explore the effect of circRNAs on DFU. In this mini-review, we discuss the potential role of circRNAs as therapeutic targets and diagnostic markers for DFU in order to gain a better understanding of the molecular mechanisms that underlie the development of DFU and to establish a theoretical basis for accurate treatment and effective prevention.
摘要：
自从人类基因组计划成功完成以来，人类已经进入了后基因组时代,而第二代测序技术也逐渐进步，并且变得更加准确。同时,circRNAs在疾病的调控中起着至关重要的作用，潜在的临床应用已逐渐引起医生的关注。然而,关于circRNAs在糖尿病足溃疡(DFU)细胞和分子水平的调控机制尚不清楚。随着研究的不断深入,最近进行了许多研究以探索circRNAs对DFU的影响。在这个小型审查中，我们讨论了circRNAs作为DFU治疗靶标和诊断标志物的潜在作用,以便更好地了解DFU发展的分子机制,并为准确治疗和有效预防建立理论基础.
