PDF(Pubmed)
Abstract：
Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are widely used in clinical cancer treatment, but the specific reproductive toxicological information is still controversial. This review described the impact and duration of taxanes on ovarian function in women and analyzed the possible reasons for different conclusions. Furthermore, the toxicity of taxanes on ovarian function and its possible mechanisms were discussed. The potential protective strategies and agents against ovarian damage induced by taxanes are also reviewed.
摘要：
化疗通常是过早卵巢功能不全和不孕症的原因，因为卵泡对化疗药物的作用极为敏感。具有不同作用机制的不同化学治疗剂可能会不同地损害卵巢功能。紫杉烷被广泛应用于临床肿瘤治疗,但具体的生殖毒理学信息仍有争议。本文就紫杉烷类药物对女性卵巢功能的影响及持续时间进行综述,并分析得出不同结论的可能原因。此外，对紫杉烷类药物对卵巢功能的毒性作用及其可能的作用机制进行了探讨。还综述了紫杉烷类引起的卵巢损伤的潜在保护策略和药物。
