Abstract：
Leptospirosis is a zoonotic disease with high prevalence in low-income and middle-income countries and tropical and subtropical regions. The clinical symptoms of the disease are similar to symptoms presented by other endemic infectious diseases that could be present simultaneously. Thus, leptospirosis could be masked by similar infections like dengue, malaria, hantavirus, melioidosis and borreliosis, among others. Therefore, leptospirosis could present itself as an under-reported infection or as a coinfection with another pathogen, as has been reported in the literature. However, there is a lack of documented evidence about the specific risk factors of leptospirosis infection, the symptoms, the coinfection\'s mortality and the frequency of coinfection. Additionally, leptospirosis coinfections have not been considered a neglected public health concern. Therefore, this systematic review aims to evaluate published articles that show the risk factors associated with leptospirosis infection and coinfection with other pathogens.
The search process to identify eligible studies will be conducted including the LILACS, ProQuest, PubMed and Scopus databases with no restriction in terms of publication date. Also, grey literature will be included in the research. Authors will independently screen the title and abstracts of the articles identified from the search using Rayyan free software. Eligibility criteria include peer-reviewed research articles written in English or Spanish, including observational studies, cohorts, case-control, cross-sectional, ecological studies and report cases. The systematic review will include studies that report descriptions of leptospirosis cases with coinfection or co-occurrence. The search will be accomplished by articles from 1950 to May 2022. The data will be extracted in a standard extraction form using an Excel format.
Results will be published in a peer-reviewed journal. Also, findings will be disseminated through scientific meetings. Ethical approval will not be required as this is a systematic review and primary data will be not collected or included.
CRD42021234754.
The search process to identify eligible studies will be conducted including the LILACS, ProQuest, PubMed and Scopus databases with no restriction in terms of publication date. Also, grey literature will be included in the research. Authors will independently screen the title and abstracts of the articles identified from the search using Rayyan free software. Eligibility criteria include peer-reviewed research articles written in English or Spanish, including observational studies, cohorts, case-control, cross-sectional, ecological studies and report cases. The systematic review will include studies that report descriptions of leptospirosis cases with coinfection or co-occurrence. The search will be accomplished by articles from 1950 to May 2022. The data will be extracted in a standard extraction form using an Excel format.
Results will be published in a peer-reviewed journal. Also, findings will be disseminated through scientific meetings. Ethical approval will not be required as this is a systematic review and primary data will be not collected or included.
CRD42021234754.
摘要：
背景：钩端螺旋体病是一种人畜共患疾病，在低收入和中等收入国家以及热带和亚热带地区患病率很高。该疾病的临床症状与可能同时存在的其他地方性传染病所呈现的症状相似。因此，钩端螺旋体病可能被类似的感染掩盖，比如登革热，疟疾,汉坦病毒,类lioidosis和borreliosis,在其他人中。因此,钩端螺旋体病可能表现为报道不足的感染或与另一种病原体的共感染，正如文献中所报道的那样。然而,缺乏关于钩端螺旋体感染的具体危险因素的证据，症状,合并感染的死亡率和合并感染的频率。此外,钩端螺旋体病合并感染尚未被视为被忽视的公共卫生问题。因此,本系统综述旨在评估已发表的文章，这些文章显示与钩端螺旋体病感染和与其他病原体合并感染相关的危险因素。
方法：确定合格研究的搜索过程将包括LILACS，ProQuest,PubMed和Scopus数据库，发布日期没有限制。此外，灰色文献将被纳入研究。作者将使用Rayyan免费软件独立筛选搜索中确定的文章的标题和摘要。资格标准包括用英语或西班牙语撰写的同行评审研究文章，包括观察性研究,同伙,病例控制，横截面,生态研究和报告案例。系统评价将包括报告钩端螺旋体病合并感染或同时发生的描述的研究。搜索将由1950年至2022年5月的文章完成。将使用Excel格式以标准提取形式提取数据。
背景：结果将发表在同行评审的期刊上。此外，研究结果将通过科学会议传播。将不需要道德批准，因为这是一个系统的审查，原始数据将不会被收集或包括在内。
UNASSIGNED：CRD42021234754。
方法：确定合格研究的搜索过程将包括LILACS，ProQuest,PubMed和Scopus数据库，发布日期没有限制。此外，灰色文献将被纳入研究。作者将使用Rayyan免费软件独立筛选搜索中确定的文章的标题和摘要。资格标准包括用英语或西班牙语撰写的同行评审研究文章，包括观察性研究,同伙,病例控制，横截面,生态研究和报告案例。系统评价将包括报告钩端螺旋体病合并感染或同时发生的描述的研究。搜索将由1950年至2022年5月的文章完成。将使用Excel格式以标准提取形式提取数据。
背景：结果将发表在同行评审的期刊上。此外，研究结果将通过科学会议传播。将不需要道德批准，因为这是一个系统的审查，原始数据将不会被收集或包括在内。
UNASSIGNED：CRD42021234754。
