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Abstract：
Immunoglobulin G4-related disease (IgG4 RD) has a fair prognosis but its diagnosis has been difficult due to the condition\'s wide range of clinical manifestations, limited awareness among common practitioners, and various differentials. Here, we present a case of an elderly male who presented with recurrent dental caries, recurrent sinusitis, persistent dry mouth, and dry eyes along with bilateral parotid gland enlargement without any lymphadenopathy. The patient was evaluated further and found to have elevated levels of IgG4 and on histopathological examination of the parotid gland showed lymphocytic infiltrate with germinal centers without any granulomatous lesions and IgG4-positive plasma cells on immunohistochemistry (IHC). The patient was diagnosed with IgG4 RD and was started on corticosteroids, after which there was a symptomatic improvement.
摘要：
免疫球蛋白G4相关疾病(IgG4RD)预后良好,但由于其临床表现广泛,诊断困难,普通从业者的意识有限，和各种差异。这里,我们介绍了一个老年男性的病例，他出现了复发性龋齿，复发性鼻窦炎,持续的口干，干眼伴双侧腮腺肿大，无淋巴结肿大。进一步评估患者，发现IgG4水平升高，腮腺组织病理学检查显示淋巴细胞浸润，生发中心无任何肉芽肿性病变，免疫组织化学（IHC）显示IgG4阳性浆细胞。患者被诊断为IgG4RD，并开始使用皮质类固醇，之后症状有所改善。
